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roles of focal adhesion kinase (protein tyrosine kinase 2, PTK2), the shear-dependent collagen receptor GPR56 (ADGRG1 gene), and calcium and integrin-binding protein 1 (CIB1). peptides that interfered with integrin αIIb binding (pCIB and pCIBm) or mimicked the activation of GPR56 integrin αIIbβ3, and CIB1 in collagen- and GPVI-dependent thrombus formation, which is modulated by GPR56

Adhesion GPCRs Downstream signaling of the disease associated mutations on GPR56/ADGRG1. Summit, Boston MA Pathios Therapeutics Unveils PTT-4256, a Highly Potent and Selective Inhibitor of GPR65

When I started studying aGPCRs, the structural conformation of the GAIN domain of ADGRL1/Lphn1 and ADGRB3 interested in studying these proteins and this year the transmembrane structures of the aGPCRs ADGRL3/Lphn3, ADGRG1 /GPR56, ADGRG5/GPR114, ADGRD1/GPR133, ADGRF1/GPR110, ADGRG2/GPR64, and ADGRG4/GPR112 were reported in Qu, X., et al., Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1. Xiao, P., et al., Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4.

October 2022 Increased Anxiety-like Behaviors in Adgra1-/- Male But Not Female Mice are Attributable We found that Adgra1 is highly and exclusively expressed in the brain, suggesting that Adgra1 may be To this end, we comprehensively analyzed the potential role of ADGRA1 in the neurobehaviors of mice by comparing Adgra1-/- and their wild-type (wt) littermates. We found that Adgra1-/- male but not female mice exhibited elevated anxiety levels in the open field,

presented this important pre-clinical work at SIRS2022 confirming the ability of the highly selective novel GPR52 important interplay between the adenosinergic and dopaminergic systems and suggests the potential for GPR52

October 2022 "The very large G protein-coupled receptor (VLGR1, ADGRV1) is the largest member of the

Adhesion GPCRs Collagen VI Is a Gi-Biased Ligand of the Adhesion GPCR GPR126/ADGRG6. Hexahydroquinoline Derivatives are Selective Agonists for the Adhesion G Protein-Coupled Receptor ADGRG1 /GPR56.

Dintzner, Demet Araç, et al. for their work on The far extracellular CUB domain of the adhesion GPCR ADGRG6 triggers peristalsis and labels tick midgut muscles The far extracellular CUB domain of the adhesion GPCR ADGRG6 treatment markers in hepatocellular carcinoma via GPCR-related genes analysis Reviews, GPCRs, and more GPR56

from June 24th to 30th, 2024 Adhesion GPCRs Novel Isoforms of Adhesion G Protein-Coupled Receptor B1 (ADGRB1 adhesion-GPCR ADGRF5 fuels breast cancer progression by suppressing the MMP8-mediated antitumorigenic effects GPR56

research position Adhesion GPCRs Loss of cardiomyocyte-specific Adhesion G Protein Coupled Receptor G1 (ADGRG1 /GPR56) promotes pressure overload-induced heart failure GPCR Activation and Signaling Positive allosteric

Adhesion GPCRs A screen of pharmacologically active compounds to identify modulators of the Adgrg6/Gpr126 High expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma Sosei Heptares Doses First Subject in Phase I Trial with HTL0048149, a First-in-Class GPR52 Agonist for

N-terminus in discriminating the endocytic effects of opioid agonist drugs GPCRs in Oncology and Immunology GPR56

GPCR Binders, Drugs, and more An antibody-drug conjugate targeting GPR56 demonstrates efficacy in preclinical

Neuroscience Molecular insights into orphan G protein-coupled receptors relevant to schizophrenia Re-routing GPR56

contributes to immune characteristics of microenvironment and process of EBV-induced lymphomagenesis GPR56

  Postdoctoral Position Postdoctoral research position Adhesion GPCRs The G Protein-Coupled Receptor GPR56

Adhesion GPCRs GPR56 C-terminal fragment mediates signal received by N-terminal fragment of another adhesion

determinants of CBD in two closely related endocannabinoid-activated GPCRs, the G-protein-coupled receptor 55 (GPR55 microsecond-length unbiased molecular dynamics simulations, we found that the presence of the CBD ligand in the GPR55 In contrast, when the GPR55 receptor is simulated in complex with the selective agonist ML186, agonist-like modulatory function of each ligand, showing that the computational techniques utilized to characterize the GPR55 From our detailed characterization, we found particular interacting loci in the binding sites of the GPR55

receptor mayo/CG11318 controls midgut development in Drosophila Structure, ligands, and roles of GPR126/ADGRG6 G-protein-coupled receptor rhodopsin activation GPCR Binders, Drugs, and more Chimeric antigens displaying GPR65

programmable sensing and control of cell behaviour GPCR Binders, Drugs, and more Exploring potential GPR55 accuracy in ligand-bound G protein-coupled receptors Molecular insights into the activation mechanism of GPR156

Latrophilin-1 controls multiple processes in reproduction of C. elegans The G protein-coupled receptor ADGRG6 Compounds: Potential Therapeutic Targets for the Treatment of Neurological Disease s Activation of GPR55

Activation of the proton-sensing GPCR, GPR65 on fibroblast-like synoviocytes contributes to inflammatory Biochemist/Structural Biologist GPCR Activation and Signaling Activation of the proton-sensing GPCR, GPR65

region of the aGPCR ADGRL3, and specifically acts as an agonist for ADGRL3 but not for its isoform, ADGRL1

Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 ( Adgrf1 Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1

Gregory Tall and team's study on GPR114/ADGRG5, activated by tethered-peptide-agonist, a cleaved adhesion Adhesion GPCRs GPR114/ADGRG5 is activated by its tethered-peptide-agonist because it is a cleaved adhesion

Here, we report the cryo-electron microscopy structures of GPR110 (ADGRF1), a member of aGPCR, in complex

Dietzsch, Simone Prömel, et al. for their work on the Dysfunction of the adhesion GPCR latrophilin 1 (ADGRL1 to 28th, 2024 Adhesion GPCRs Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1

In addition, hearing loss can be caused by mutations of certain GPCRs, such as Vlgr1, Gpr156, S1P2, and