< GPCR News < GPCRs in Oncology and Immunology GPR68-ATF4 signaling is a novel prosurvival pathway in Notably GPR68, an acid sensing GPCR, is upregulated in radioresistant GBM. Usage of Lorazepam, which has off target agonism of GPR68, is linked to worse clinical outcomes for a To determine GPR68 inhibition's mechanism of cell death we use DAVID pathway analysis of RNAseq. In this context, GPR68 suppresses ATF4, inhibition of GPR68 increases expression of ATF4 which leads

< GPCR News < GPCRs in Oncology and Immunology GPR56 signaling pathway network and its dynamics in the transition of glioblastoma Published date November 19, 2023 Abstract "G protein-coupled receptor 56 (GPR56 In our earlier study, we reported that GPR56 is expressed heterogeneously in glioblastoma (GBM) and is plausible cross-connectivity across different axes attributable to GPR56 function. GPR56 signaling and mesenchymal transition."

< GPCR News < GPCRs in Oncology and Immunology GPR4 in the pH-dependent migration of melanoma cells in Membrane-bound receptors, such as the proton-sensitive GPCR (pH-GPCR) GPR4, are considered as potential In this study, we investigated the pH-dependent migration of GPR4 wildtype/overexpressing SK-Mel-28 cells Migration of GPR4 overexpressing SK-Mel-28 cells was enhanced in a range of pH 6.5 - pH 7.5 as compared In Boyden chamber experiments, GPR4 overexpression only increased migration at pH 7.5 in a Matrigel-free

< GPCR News < GPCRs in Oncology and Immunology GprC of the nematode-trapping fungus Arthrobotrys flagrans However, GprC and GasA also reside in mitochondria and boost respiration. This dual localization of GprC in A. flagrans resembles the localization of the cannabinoid receptor An SRBC64/66-GprC chimaeric protein was functional in A. flagrans, and C. elegans SRBC64/66 and DAF38 share ascaroside-binding sites with the fungal GprC receptor, suggesting 400-million-year convergent

Oncology and Immunology Glucose and HODEs regulate Aspergillus ochraceus quorum sensing through the GprC-AcyA Moreover, the GprC that classified as sugar sensor, and intracellular adenylate cyclase (AcyA)-cAMP-PKA Furthermore, GprC and AcyA regulate the primary metabolism as well as secondary metabolism, and further

We also identified DHEA, DHEAS and DOC are endogenous ligands of GPR64 etc (Nature, 2021a, Nat Chem Biol We also identified that orphan receptor GPR64 forms complex with β-arrestin-1 and CFTR at apical membrane

ADGRC1) In Breast Cancer Caroline Formstone Generation and characterization of collecting duct specific GPR56 knockout mice Jianxiang Xue Abstract "GPR56 is a multifunctional adhesin G protein-coupled receptor The role of GPR56 in the kidneys has been understudied. GPR56 knockout (GPR56CD-KO) mouse model by crossing GPR56flox (Control) with cadherin 16 Cre mice. The deletion of GPR56 in the collecting duct was confirmed by RNAscope ISH.

Sign Up Latest Classified GPCR News Adhesion GPCRs September 25, 2024 The G Protein-Coupled Receptor GPR56 More September 12, 2024 Loss of cardiomyocyte-specific Adhesion G Protein Coupled Receptor G1 (ADGRG1/GPR56

I studied the function of RGS5, calcium-sensing receptor, and an orphan adhesion GPCR, GPR64/ADGRG2 in

Using receptor chimera of G protein-coupled receptor 1 (GPR1) and CMKLR1, we were able to identify the

actions of the neuroprotective receptors GPR37 & GPR37L1 as well as the adhesion GPCRs BAI1, BAI2, and GPR56

Frank Kwarcinski Discriminating between the extracellular scaffolding and G protein signaling roles of GPR56 GPCR ADGRL1 / Latrophilin-1 Jianxiang Xue Generation and characterization of collecting duct specific GPR56 Zou ADGRCs in glutamatergic synapse formation, maintenance and degeneration Cheng-Chih Hsiao ADGRG1/GPR56

may happen for the 33 adhesion GPCRs in complex physiological contexts…one being our discovery that GPR56

The team found that these drugs could interact with GPR68, which is highly expressed in cancer-associated Modulation Yamina and Mike had a discussion about their research on GPCRs, specifically focusing on GPR68