behavior and learning GPCRs in Oncology and Immunology Short-chain fatty acids and cancer The path of GPR87

GPR84 is an example. Expression of GPR84 is strongly up regulated in immune cells in a range of pro-inflammatory settings Although blockade of GPR84 may potentially prove effective also in diseases associated with inflammation Here, we consider the physiological and pathological expression profile of GPR84 and, in the absence of direct structural information, recent developments and use of GPR84 pharmacological tool compounds

GPCRs in Cardiology, Endocrinology, and Taste Integrated bioinformatics analysis reveals that CCBP2 and GPR87 of liposome encapsulated flavonoids ameliorates l-DOPA induced dyskinesia in hemiparkinsonian mice GPR88

< GPCR News < GPCRs in Oncology and Immunology The path of GPR87: from a P2Y-like receptor to its role in cancer progression Published date December 6, 2024 Abstract "GPR87 is a G protein-coupled seven-transmembrane surface receptor, these data are preliminary and inconsistent, and IUPHAR is currently considering GPR87 Thus, the endogenous ligands and physiological functions of GPR87 are still required to be determined Therefore, in this review article, the main focus is placed on the oncogenic role of GPR87 in various

We detected the expression of GPR37 in NSCLC tissues and cell lines. The study explored the influence of GPR37 on tumor cell proliferation. Furthermore, we examined the effects of GPR37 on tumor cell apoptosis and invasion. Most importantly, we investigated whether GPR37 affects cisplatin-induced drug resistance in NSCLC. Knockdown of GPR37 significantly inhibits the occurrence and development of NSCLC.

< GPCR News < GPCRs in Oncology and Immunology Lactate receptor GPR81 drives breast cancer growth and and Notch ligand DLL4 Published date November 22, 2023 Abstract " Background: The lactate receptor GPR81 Here, we investigate the roles of GPR81 in three-dimensional (3D) and in vivo growth of breast cancer Methods: GPR81 was stably knocked down (KD) in MCF-7 human breast cancer cells which were subjected to Our findings reveal a new GPR81-driven mechanism in breast cancer and substantiate GPR81 as a promising