< GPCR News < GPCRs in Oncology and Immunology GPR97 depletion aggravates imiquimod-induced psoriasis In this research, our team allocated GPR97 depletion (GPR97-/-), GPR97 conditional depletion on dendritic cell (DC-cKO), and keratin 14-conditional knockout (K14-cKO) mice models to explore the function of GPR97 It was found that significantly aggravated psoriasis-like lesion in GPR97-/- mice. Particularly, we found that level of NF-κB p65 was increased in GPR97-/- DCs and BDP could inhibit p65

For instance, membrane receptor GPR97 is able to sense glucocorticoid to mediate its rapid actions, the

Expressed Gpr116 (Adgrf5) Transcript Variants in Mouse Kidney Hailey Steichen Elucidating The Role Of GPR97 Hailey Steichen on the web Zaidman Physiology Lab Elucidating The Role Of GPR97/ADGRG3 In Neutrophil

Sensor Approach for Drug Discovery for Human Adhesion GPCRs Tyler Bernadyn Elucidating The Role Of GPR97

We detected the expression of GPR37 in NSCLC tissues and cell lines. The study explored the influence of GPR37 on tumor cell proliferation. Furthermore, we examined the effects of GPR37 on tumor cell apoptosis and invasion. Most importantly, we investigated whether GPR37 affects cisplatin-induced drug resistance in NSCLC. Knockdown of GPR37 significantly inhibits the occurrence and development of NSCLC.

< GPCR News < GPCRs in Oncology and Immunology GPR37 expression as a prognostic marker in gliomas: a GPR37 is an orphan G protein-coupled receptor (GPCR) that is implicated in different physiological pathways Results: GPR37 expression was significantly higher in the glioma tissues compared to the normal brain Furthermore, GPR37 was positively correlated with various immune checkpoints (ICPs). Conclusion: GPR37 had diagnostic and prognostic value in glioma.

< GPCR News < GPCRs in Oncology and Immunology GPR37 promotes colorectal cancer against ferroptosis by This study demonstrates that GPR37, a GPCR receptor, is highly expressed in CRC. Depletion of GPR37 significantly reduced CRC tumor cell growth both in vitro and in vivo. Further tests showed that GPR37 protects cancer cells from ferroptosis by upregulating SCD1 expression Our results reveal the pro-carcinogenic effect of GPR37 in primary CRC and suggest that targeting GPR37

Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 We report that efferocyte-derived EVs express prosaposin, which binds to macrophage GPR37 to increase

interact with a set of genomically related transmembrane receptors, like C5aR1 (CD88, C5aR) and C5aR2 (GPR77

contributions to understanding the signaling, regulation and in vivo actions of the neuroprotective receptors GPR37