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2 items found for "GPRC5D"
- Structural Basis for the Recognition of GPRC5D by Talquetamab, a Bispecific Antibody for Multiple Myeloma
< GPCR News < GPCRs in Oncology and Immunology Structural Basis for the Recognition of GPRC5D by Talquetamab G-protein-coupled receptor class C group 5 member D (GPRC5D), an orphan GPCR predominantly expressed microscopy, providing the basis for recognition of GPRC5D by the bispecific antibody. GPRC5D forms a symmetric homodimer with the interface between transmembrane helix (TM) 4 of one protomer The structure offers insights for optimizing antibody design against GPRC5D for relapsed or refractory
- [Inhibitory effect of downregulating G protein-coupled receptor class C group 5 member A expression on lipopolysaccharide-induced inflammatory response in human gingival fibroblasts]
The expressions of GPRC5A of the two groups were detected by immunohistochemistry staining. by RT-qPCR and Western blotting analysis after GPRC5A knockdown. Meanwhile, RT-qPCR results showed that the gene expression levels of GPRC5A at different time point ( The siGPRC5A+LPS group (0.39±0.03, 1.06±0.16) also inhibited the increase of GPRC5A at both gene and Conclusions: GPRC5A expression was upregulated in periodontitis, and GPRC5A knockdown inhibited LPS-induced