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49 items found for "GRK"

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  • Combinatorial depletions of G-protein coupled receptor kinases in immune cells identify pleiotropic and cell type-specific functions

    type-specific functions Published date November 1, 2022 Abstract G-protein coupled receptor kinases (GRKs However, there is growing evidence that GRKs can also control cellular functions beyond GPCR regulation Immune cells commonly express two to four members of the GRK family (GRK2, GRK3, GRK5, GRK6) simultaneously In particular, we are missing comprehensive studies comparing the role of this GRK interplay for (a) To address this issue, we generated mouse models of single, combinatorial and complete GRK knockouts

  • Chemoattractant receptor signaling in humoral immunity

    After ligand binding, GPCRs are phosphorylated by different GPCR kinases (GRKs) at distinct sites on However, the molecular mechanisms by which individual GRKs are selectively targeted to GPCRs have been domain-containing (COMMD) 3 and 8 (COMMD3/8 complex) functions as an adaptor that recruits a specific GRK Authors Taiichiro Shirai , Akiko Nakai , Kazuhiro Suzuki Tags B cell migration , COMMD3/8 complex , GRK

  • Ep 112 with Julia Gardner

    She recently led a project that demonstrated the GPCR kinases (GRKs) can translocate to endosomes, and that the subcellular localization of the GRKs affects a GPCR's biased signaling profile.

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