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49 items found for "GRK"
Posts (34)
- GPCR kinase phosphorylation of distal C-tail sites specifies βarrestin1-mediated signaling by...
September 2022 "G protein-coupled receptor (GPCR) kinases (GRKs) and arrestins mediate GPCR desensitization The spatial pattern of GPCR phosphorylation is predicted to trigger these discrete GRK and arrestin-mediated We demonstrate by pharmacologic inhibition of GRK2/3-mediated phosphorylation of the chemokine receptor In conclusion, this study provides evidence that distal C-tail phosphorylation sites specify GRK-βarrestin-mediated
- GPCR kinases generate an APH1A phosphorylation barcode to regulate amyloid-β generation
August 2022 "Emerging evidence suggests that G protein-coupled receptor (GPCR) kinases (GRKs) are associated However, GRKs have not been directly implicated in regulation of the amyloid-β (Aβ) pathogenic cascade Here, we determine that GRKs phosphorylate a non-canonical substrate, anterior pharynx-defective 1A ( Significantly, we show that GRKs generate distinct phosphorylation barcodes in intracellular loop 2 (
- β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the...
Employing GRK knockout cells and β-arrestins lacking the finger-loop-region, we show that the two isoforms specifically by proximal and distal C-terminal phosphorylation and in the absence of GPCR kinases (GRKs
Other Pages (15)
- Combinatorial depletions of G-protein coupled receptor kinases in immune cells identify pleiotropic and cell type-specific functions
type-specific functions Published date November 1, 2022 Abstract G-protein coupled receptor kinases (GRKs However, there is growing evidence that GRKs can also control cellular functions beyond GPCR regulation Immune cells commonly express two to four members of the GRK family (GRK2, GRK3, GRK5, GRK6) simultaneously In particular, we are missing comprehensive studies comparing the role of this GRK interplay for (a) To address this issue, we generated mouse models of single, combinatorial and complete GRK knockouts
- Chemoattractant receptor signaling in humoral immunity
After ligand binding, GPCRs are phosphorylated by different GPCR kinases (GRKs) at distinct sites on However, the molecular mechanisms by which individual GRKs are selectively targeted to GPCRs have been domain-containing (COMMD) 3 and 8 (COMMD3/8 complex) functions as an adaptor that recruits a specific GRK Authors Taiichiro Shirai , Akiko Nakai , Kazuhiro Suzuki Tags B cell migration , COMMD3/8 complex , GRK
- Ep 112 with Julia Gardner
She recently led a project that demonstrated the GPCR kinases (GRKs) can translocate to endosomes, and that the subcellular localization of the GRKs affects a GPCR's biased signaling profile.