Search Results

A recent focus on GPCR intracellular-regulating proteins such as GPCR kinases (GRKs) has uncovered GRK2 Current literature strongly establishes increased levels and activity of GRK2 in multiple models of CVD Additionally, the GRK2 interactome includes numerous proteins which interact with differential domains of GRK2 to modulate both beneficial and deleterious signaling pathways in the heart, indicating that These data support the premise that GRK2 should be at the forefront of a novel investigative drug search

as a biomarker of oral squamous cell carcinoma (OSCC) by regulating the signaling pathway of miR-19a/GRK6

GPCR-kinase 3 (GRK3) is critical for GPCR signaling. However, GRK3’s functions and clinical utility in GAC progression and metastases are unknown. Methods We studied GRK3 expression in normal, primary, and metastatic GAC tissues. We identified a novel GRK3 inhibitor, LD2, through a chemical-library screen. Impact of GRK3 on YAP1 and its targets was determined."

analysis and luciferase assays were performed to establish a potential signaling pathway of miR-19a/GRK6 Results: We found that miR-19a, GPR39 mRNA and PKC mRNA were upregulated while GRK6 mRNA was downregulated Moreover, in silico analysis confirmed a potential binding site of miR-19a on the 3'UTR of GRK6 mRNA, and the subsequent luciferase assays confirmed the molecular binding between GRK6 and miR-19a. We further identified that the over-expression of miR-19a could regulate the signaling between GRK6,

type-specific functions Published date November 1, 2022 Abstract G-protein coupled receptor kinases (GRKs However, there is growing evidence that GRKs can also control cellular functions beyond GPCR regulation Immune cells commonly express two to four members of the GRK family (GRK2, GRK3, GRK5, GRK6) simultaneously In particular, we are missing comprehensive studies comparing the role of this GRK interplay for (a) Combined depletion of GRK2 and GRK6 in T cells and B cells shows distinct functional outcomes for (a)

as a biomarker of oral squamous cell carcinoma (OSCC) by regulating the signaling pathway of miR-19a/GRK6 Wang , Danhua Ma , He Zhang , Jiayan Fan , Hongyan Gao , Xinyu Xia , Wei Wu , Yuyuan Shi Tags GPCR , GRK6