Search Results
63 items found for "Genome sequence"
- From DNA day to GPCR genomics
an organism's entire DNA or genome, including its genes, regulatory elements, and non-coding DNA sequences Genomics, in turn, played a crucial role in the discovery and sequencing of the beta-adrenergic receptor The completion of the Human Genome Project revealed that GPCR genes in the human genome range from approximately as genome sequencing technologies and bioinformatics tools improve. Advances in genomic technologies, such as genome-wide association studies and next-generation sequencing
- C5aR2 receptor: The genomic twin of the flamboyant C5aR1
C5a is established to interact with a set of genomically related transmembrane receptors, like C5aR1
- ADGRL3 genomic variation implicated in neurogenesis and ADHD links functional effects to the...
October 2022 ADGRL3 genomic variation implicated in neurogenesis and ADHD links functional effects to
- Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi...
October 2022 Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture
- High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways and...
September 2022 High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways and predicts poor patient outcomes "Triple-negative breast cancer (TNBC) is a particularly aggressive and heterogeneous disease with few effective targeted therapies and precision therapeutic options over a long period. It is generally considered that TNBC is an estrogen-independent breast cancer, while a new estrogen receptor, namely G protein-coupled estrogen receptor (GPER), is demonstrated to mediate estrogenic actions in TNBC. Based on our transcriptomic analysis, expression of GPER was correlated with clinicopathological variables and survival of 360 TNBC patients. GPER expression at mRNA level was significantly correlated with immunohistochemistry scoring in 12 randomly chosen samples. According to the cutoff value, 26.4% (95/360) of patients showed high GPER expression and significant correlation with the mRNA subtype of TNBC ( P = 0.001), total metastatic events ( P = 0.019) and liver metastasis ( P = 0.011). In quantitative comparison, GPER abundance is correlated with the high-risk subtype of TNBC. At a median follow-up interval of 67.1 months, a significant trend towards reduced distant metastasis-free survival (DMFS) ( P = 0.014) was found by Kaplan–Meier analysis in patients with high GPER expression. Furthermore, univariate analysis confirmed that GPER was a significant prognostic factor for DMFS in TNBC patients. Besides, high GPER expression was significantly linked to the worse survival in patients with lymph node metastasis, TNM stage III as well as nuclear grade G3 tumors. Transcriptome-based bioinformatics analysis revealed that GPER was linked to pro-metastatic pathways in our cohort. These results may supply new insights into GPER-mediated estrogen carcinogenesis in TNBC, thus providing a potential strategy for endocrine therapy of TNBC." Read more at the source #DrGPCR #GPCR #IndustryNews
- Genome-wide identification of 216 G protein-coupled receptor (GPCR) genes from the marine water ...
Genome-wide identification of 216 G protein-coupled receptor (GPCR) genes from the marine water flea GPCRs) are considered to have originated from early evolution of eukaryotic species, therefore, the genome-wide , we identified a total 216 full-length GPCR genes in the marine water flea Diaphanosoma celebensis genome
- Regulator of G Protein Signaling 20 Correlates with Long Intergenic Non-Coding RNA (lincRNAs)...
By using the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) data, our analysis revealed
- 📰 GPCR Weekly News, June 19 to 25, 2023
GPCRs in Neuroscience Whole genome sequencing across clinical trials identifies rare coding variants Octopus 3.0 - Next-Day Turnaround Of Full Plasmid Sequencing Directly From Colonies Indivior to Commence
- A new Kunitz-type snake toxin family associated with an original mode of interaction with the...
with an original mode of interaction with the vasopressin 2 receptor "Abstract Background and purpose: Venomous The mambaquaretin-1 (MQ1) peptide identified from the Dendroaspis angusticeps venom is the most selective We aimed to exploit other mamba venoms to enlarge the V2R-Kunitz peptide family and gain insight into Sequence comparison between active and non-active V2R Kunitz peptides highlighted five positions, among
- 📰 GPCR Weekly News, May 27 to June 2, 2024
Deciphering the genetic landscape of lumpy skin disease: Unraveling variable virulence through comprehensive genome sequence analysis in India Methods & Updates in GPCR Research Engineering G protein-coupled receptors
- 📰 GPCR Weekly News, March 27 to April 4, 2023
First complete genome sequence of lumpy skin disease virus directly from a clinical sample in South India
- Dr. GPCR University registration is now open! Secure your spot now!
Activating an invertebrate bistable opsin with the all-trans 6.11 retinal analog Comparison of the Genomic muscarinic acetylcholine receptor family: opportunities and challenges Modulating Vertebrate Physiology by Genomic Unveiling G-protein coupled receptors as potential targets for ovarian cancer nanomedicines: from RNA sequencing
- Harnessing Deep Mutational Scanning for Enhanced Drug Discovery
method for studying the functional consequences of various genetic variants within a specific gene or genomic This technique combines high-throughput DNA sequencing with systematic mutagenesis to create and assess Finally, current sequencing technology restricts the mutagenizable region to about 300 amino acids, although this limitation has eased from an initial 25 amino acids and is expected to further diminish as sequencing An essential advancement will be the integration of DMS with emerging sequencing technologies that allow
- GRK3 is a poor prognosticator and serves as a therapeutic target in advanced gastric adenocarcinoma
Our genomic analysis showed that GRK3 expression correlated with poor prognosis of gastric adenocarcinoma
- 📰 GPCR Weekly News, March 4 to 10, 2024
neurogliosis in female Alzheimer's mice The association of GNB5 with Alzheimer disease revealed by genomic of recombinant LSDV isolates from 2022 outbreak in Indonesia through phylogenetic networks and whole-genome
- The mouse cytomegalovirus G protein-coupled receptor homolog, M33, coordinates key features of ...
infection via distinct components of its signalling repertoire Common to all cytomegalovirus (CMV) genomes (DC)-dependent viremia, the extravasation of blood-borne infected DC to the salivary gland and the frequency All cytomegalovirus (CMV) genomes analysed to date possess GPCR homologs with phylogenetic evidence for
- Case Report of a Juvenile Patient with Autism Spectrum Disorder with a Novel Combination of Copy...
Using array-based comparative genomic hybridization (array-CGH), we identified two CNVs, both triplex
- Odorant G protein-coupled receptors as potential therapeutic targets for adult diffuse gliomas ...
Based on this systematic analysis and review of the genomic and transcriptomic profiles of ORs in glioma
- Artificial intelligence – faster, smarter, cheaper GPCR drug discovery
The models use a variety of data for the input, including amino acid sequences or structural data (from RoseTTAFold (Baek et al., 2021) allow the prediction of the 3D structure of a protein from the amino acid sequence GPCR-ligand interactions: ML can predict GPCR-ligand interactions based on input data of protein sequences Sanavia, Birolo, Montanucci, Turina, Capriotti & Fariselli, 2020) with intrinsic limitations (e.g. using sequence de Graaf & Bender, 2021) and 4) limit of input data can lead to a phenomenon called “the burden of sequence
- 📢 GPCR Update: August 19-25, 2024 | Thrilling Announcement: New Pharmacology Course Dates & Exclusive Discounts Inside!
compulsive-like grooming and anxiety-related behaviors in Sapap3 knockout mice Methods & Updates in GPCR Research Genome-wide
- 📰 GPCR Weekly News, October 23 to 29, 2023
Nanoscale Thermostability Assay Applied to GPCRs Reviews, GPCRs, and more Illuminating the druggable genome
- 📰 GPCR Weekly News, April 15 to 21, 2024
Receptors (GPCRs): a historical perspective Monserrat Avila-Zozaya article on From DNA day to GPCR genomics of Vertebrate G-Protein-Coupled Receptor Fusions United With or Without an Additional Transmembrane Sequence
- 📰 GPCR Weekly News, May 22 to 28, 2023
Structural genomics of the human dopamine receptor system Structural Insights into Molecular Recognition
- Extracellular signal-regulated kinases – a potential pathway for GPCR-targeted drug discovery
Current Chemical Genomics and Translational Medicine, 7, 9. Kenakin, T. (2019).
- 📰 GPCR Weekly News, December 18 to 31, 2023
system for numbering residues and a proposal for naming structural motifs and subfamilies Comparative genomic
- Regulators of G-protein signaling: essential players in GPCR signaling
Genomics, 2021. 113(4): p. 2134-2144. https://pubmed.ncbi.nlm.nih.gov/33845140/
- Decoding β-Arrestins: from Structure to function
tissues from the Genotype-Tissue Expression (GTEx) database with data from cancer samples in The Cancer Genome
- Adhesion GPCR Consortium Newsletter - May 2024
neuronal synapses uncovered through the mechanism of action of a paralyzing component from black spider venom