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449 items found for "Gorostiola González M"

  • Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors

    frequently exploited drug target family, moreover they are often found mutated in cancer. datasets, a mutation enrichment in cancer patients was observed among class-specific conserved motifs in GPCRs such as the Class A "DRY" motif. Authors Bongers B J , Gorostiola González M , Wang X , van Vlijmen HWT , Jespers W , Gutiérrez-de-Terán , and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research

  • The Effect of Cancer-Associated Mutations on Ligand Binding and Receptor Function - A Case for the 5-HT2C Receptor

    from multiple cancer types. These two mutations may disrupt the conserved ionic interaction between E6.30 and R3.50, and thus increase Such mutations may affect serotonin-mediated signaling in tumor cells as well as treatment strategies Authors Chenlin Feng, Rongfang Liu, Reno Brooks, Xuesong Wang, Willem Jespers, Marina Gorostiola González , and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research

  • GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to the synovium

    Recent evidence indicates that GPR15 may be associated with modulation of the chronic inflammatory response The expression of GPR15 and c10orf99/gpr15l mRNA was analyzed by RT-qPCR. Authors Julio Cesar Fernández-Ruiz, Fátima de Lourdes Ochoa-González, Martín Zapata-Zúñiga, Eduardo Mondragon-Marín , and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCR Monthly Newsletter today! Follow the Dr.

  • Ep 82 with Dr. Lauren M. Slosky

    Lauren M. Slosky About Dr. Lauren M. Medical Discovery Team on Addiction, a multidisciplinary initiative within the University of Minnesota Slosky opened her laboratory at the University of Minnesota Medical School in 2021. for genetically modified mice. Lauren M.

  • Identification of S1PR4 as an immune modulator for favorable prognosis in HNSCC through machine learning

    (CLAG-M) in a phase 1/2 trial of 81 adults aged ≤60 years with newly diagnosed AML. No maximum tolerated dose was reached, and a regimen including mitoxantrone 18 mg/m2 per day and sorafenib Comparing outcomes using CLAG-M/sorafenib with those of a matched cohort of 76 patients treated with CLAG-M alone, multivariable-adjusted survival estimates were improved for 41 patients receiving CLAG-M These data suggest that CLAG-M/sorafenib is safe and improves OS and EFS relative to CLAG-M alone, with

  • Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses in sterile and infectious inflammation

    using a novel mouse line where the expression of Gpr101 was conditionally deleted in macrophages (MacGpr101KO Peritoneal macrophages obtained from naïve MacGpr101KO mice displayed a marked shift in the expression The alterations in macrophage phenotype observed in Gpr101 deficient macrophages were maintained following in Gpr101 deficient mice, with a downregulation of pro-resolving mediators including MaR2n-3 DPA, Resolvin Authors Magdalena B Flak , Duco S Koenis , Maria Gonzalez-Nunez , Ana Chopo-Pizarro , Jesmond Dalli Tags

  • Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms and therapeutic targets in atopic diseases

    , MCP-4 , MRGPRX1 , Mas-related family of G protein-coupled receptor 11 , Mas-related family of G protein-coupled receptors , Mitogen-activated protein kinase , Monoclonal antibody , Monocyte chemoattractant protein U , OSM , OSMRβ , Oncostatin M , Oncostatin-M specific receptor subunit beta , PAR2 , PC(20) , PN , potential , Transient receptor potential ankyrin 1 , Transient receptor potential cation channel subfamily M member 4 , Transient receptor potential cation channel subfamily M member 8 , Transient receptor potential

  • Phase 1/2 study of sorafenib added to cladribine, high-dose cytarabine, G-CSF, and mitoxantrone in untreated AML

    Authors Anna B Halpern , Eduardo Rodríguez-Arbolí , Megan Othus , Kelsey-Leigh A Garcia , Mary-Elizabeth M Percival , Ryan D Cassaday , Vivian G Oehler , Pamela S Becker , Jacob S Appelbaum , Janis L Abkowitz , Johnnie J Orozco , Siobán B Keel , Paul C Hendrie , Bart L Scott , M Cristina Ghiuzeli , Elihu H Estey , and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCR Monthly Newsletter today! Follow the Dr.

  • Delivery of US28 by incoming HCMV particles rapidly attenuates Akt activity to suppress HCMV lytic replication in monocytes

    We investigated the mechanisms through which HCMV establishes a quiescent infection in monocytes. Authors Jamil Mahmud, Brittany W Geiler, Juthi Biswas, Michael J Miller, Julia E Myers, Stephen M Matthews , Amanda B Wass, Christine M O'Connor, Gary C Chan Source Contribute to the GPCR News Coming soon Become , and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCR Monthly Newsletter today! Follow the Dr.

  • Identification of a G-protein coupled receptor-related gene signature through bioinformatics analysis to construct a risk model for ovarian cancer prognosis

    The predictive ability of the model was evaluated by Kaplan-Meier (K-M) survival analysis. K-M analysis of the prognostic model showed that it could differentiate high- and low-risk patients, Authors Shaohan Ma, Ruyue Li, Guangqi Li, Meng Wei, Bowei Li, Yongmei Li, Chunfang Ha Tags G protein-coupled receptor , Immune infiltration , Molecular marker , Ovarian cancer , Prognostic model , epithelial Source , and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research

  • G protein-coupled estrogen receptor (GPER)/GPR30 forms a complex with the β1-adrenergic receptor, a membrane-associated guanylate kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer cells

    guanylate kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast which they interact in the plasma membrane with membrane-associated guanylate kinase (MAGUK) scaffold MCF7 breast cancer cells express GPR30, β1AR, MAGUKs, and AKAP5 in the plasma membrane, and co-immunoprecipitation Authors Julia Tutzauer , D Stephen Serafin , Tobias Schmidt , Björn Olde , Kathleen M Caron , L M Fredrik , and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research

  • Ep 103 with Dr Kathleen Caron

    Kathleen Caron About Kathleen M. Caron Kathleen M. Caron, Ph.D. is the Frederik L. steroidogenesis in regulating sexual determination and adrenal and gonadal development using genetic mouse models. With a special emphasis on G protein coupled receptors and receptor activity modifying proteins in vascular Kathleen M.

  • Protease-Activated Receptor-1 IgG Autoantibodies in Patients with COVID-19

    Anne-Christin Beatrice Wilde, Pegah Ramezani Rad, Wolfgang Poller, Erik Asmus, Szandor Simmons, Wolfgang M Kuebler, Martin Witzenrath, Lajos Markó, Kai Jakobs, Marianna Puccini, David M Leistner, Ursula Rauch-Kröhnert , and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research insights into GPCR function GPCR Activation and Signaling More from Dr. GPCR Monthly Newsletter today! Follow the Dr.

  • Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19

    These might serve as allosteric agonists of PAR1 on endothelial cells and platelets, and thus might contribute Authors Florian Tran , Danielle M M Harris , Alena Scharmacher , Hanna Graßhoff , Kristina Sterner , Susanne Schinke , Nadja Käding , Jens Y Humrich , Otávio Cabral-Marques , Joana P Bernardes , Neha Mishra , and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCR Monthly Newsletter today! Follow the Dr.

  • Interaction with the cell adhesion molecule NEGR1 affects mGluR5 cell signalling

    About Fabiola Ribeiro "Fabiola M. Ribeiro is an Associate Professor at the Universidade Federal de Minas Gerais (UFMG). Moreover, Dr. Ribeiro is the first or last author of 33 of these published articles. Dr. Ribeiro main scientific contributions include the study of the mechanisms involved in neurodegeneration These drugs were shown to be very effective to rescue the cell death observed in a mouse model of Huntington

  • Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation

    Here we used zebrafish and mouse models to probe the role of BLT2 in macrophage function during inflammation We detected BLT2 expression in bone marrow derived and peritoneal macrophages of mouse models. Transcriptomic analysis of Ltb4r2-/- and WT macrophages suggested a role for BLT2 in macrophage migration Authors Ebru Ermis , Titli Nargis , Kierstin Webster , Sarah A Tersey , Ryan M Anderson , Raghavendra G Mirmira Tags G-protein coupled receptor (GPCR) , Macrophage , inflammation , metabolism , mouse ,

  • Blockade of vasoactive intestinal peptide receptor 2 (VIPR2) signaling suppresses cyclin D1-dependent cell-cycle progression in MCF-7 cells

    The percentage of cells in the S-M phase was decreased in MCF-7 cells treated with KS-133. and did not affect the effect of the mixture of these inhibitors. , and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research insights into GPCR function GPCR Activation and Signaling More from Dr. GPCR Monthly Newsletter today! Follow the Dr.

  • Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration, proliferation, and signaling

    Methods/results: Here, we measured the effects of NPY1R and NPY5R antagonists in normoxia and hypoxia on migration, proliferation, invasion, and signaling in 2D and 3D models of breast cancer cell lines MDA-MB-231 and MCF7. Authors Sydney A Pascetta , Sarah M Kirsh , Makenna Cameron , James Uniacke . , and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research

  • Distinct Activation Mechanisms of CXCR4 and ACKR3 Revealed by Single-Molecule Analysis of their Conformational Landscapes

    indirectly influencing migration. Authors Christopher T Schafer, Raymond F Pauszek 3rd, Martin Gustavsson, Tracy M Handel, David P Millar , and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research insights into GPCR function GPCR Activation and Signaling More from Dr. GPCR Monthly Newsletter today! Follow the Dr.

  • Systems Pharmacodynamic Model of Combination Gemcitabine and Trabectedin in Pancreatic Cancer Cells. Part II: Cell Cycle, DNA Damage Response, and Apoptosis Pathways

    To investigate potential mechanisms underlying this synergistic pharmacodynamic interaction, liquid chromatography-mass The SPD model was subsequently incorporated into our previously-established cell cycle model, forming a comprehensive, multi-scale quantification platform for evaluating drug effects across multiple scales M Straubinger , William J Jusko Tags Systems Pharmacodynamic , drug combination , gemcitabine , pancreatic , and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research

  • Spliceosome mutations are associated with clinical response in a phase 1b/2 study of the PLK1 inhibitor onvansertib in combination with decitabine in relapsed or refractory acute myeloid leukemia

    to those without SF mutations (9%). S Wang , Amer M Zeidan Tags AML , Biomarker , Hypomethylating agents , Onvansertib , PLK1 , Splicing , and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research insights into GPCR function GPCR Activation and Signaling More from Dr. GPCR Monthly Newsletter today! Follow the Dr.

  • Comparison of infectious complications with BCMA-directed therapies in multiple myeloma

    myeloma Published date May 31, 2024 Abstract "B-cell-maturation-antigen (BCMA)-directed therapies are highly active for multiple myeloma, but infections are emerging as a major challenge. Scordo, Gunjan L Shah, Hani Hassoun, Kylee Maclachlan, Neha Korde, Urvi A Shah, Carlyn Rose Tan, Malin Hultcrantz, Sergio A Giralt, Saad Z Usmani, Zainab Shahid, Sham Mailankody, Alexander M Lesokhin Source , and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research

  • Removing the GPCR-mediated brake on exocytosis enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity

    McGuinness 5, Sheila Collins 1,5, Heidi E. Hamm 2 1 Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center Hamm, Ph.D. is the Aileen M. Her research focuses on the structure and function of GTP binding proteins and the molecular mechanisms has made key discoveries in G protein structure and mechanisms of activation by GPCRs and activation

  • Ep 75 with Vaithish Velazhahan

    Vaithish Velazhahan About Vaithish Velazhahan Vaithish obtained dual bachelor’s degrees with honors in Medical Biochemistry and Microbiology from Kansas State University, USA. magnetic resonance spectroscopy (NMR) led to a Barry M. This work has led to two first-authored manuscripts published in the journal Nature. Vaithish has been recognized with the MRC LMB's Max Perutz Prize for outstanding Ph.D. work and has been

  • Chemokine N-terminal-derived peptides differentially regulate signaling by the receptors CCR1 and CCR5

    a highly diverse manner. as CCR5-selective modulators." M Rosenkilde Tags GPCR , allosteric modulation , chemokine , chemokine truncation , pharmacology Source , and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCR Monthly Newsletter today! Follow the Dr.

  • In Silico Design of Novel RGS2-Galpha-q Interaction Inhibitors with Anticancer Activity

    Thus, RGS proteins are essential in regulating GPCR signaling, and most members are implicated as critical in many solid breast cancers, and its levels in prostate cancer significantly correlate with the metastatic Roman, Tarek M Mahfouz Source Contribute to the GPCR News Coming soon Become a Contributor Classified Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research GPCRs in Neuroscience GPCR Monthly Newsletter today! Follow the Dr.

  • The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure

    However, many cancers do not respond to ICB, prompting the search for additional strategies to achieve J Song , Meghana S Pagadala , Lauren M Clubb , Joshua Chiou , Sanju Sinha , Marin Matic , Francesco , and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research insights into GPCR function GPCR Activation and Signaling More from Dr. GPCR Monthly Newsletter today! Follow the Dr.

  • Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion

    Analysing the main members of the PDAC extracellular purinome using publicly available databases discerned which members may impact patient survival. Using genetic modification and pharmacological strategies we demonstrate mechanistically that this ATP-driven Qiaoying Wang , Edward Philip Carter , Nicolas Jaime Roth , Jessica Gibson , Ariana Samadi , Hemant M , and Webinars Reviews, GPCRs, and more GPCR Binders, Drugs, and more Methods & Updates in GPCR Research

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