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October 2022 Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered mechanism "The mechanistic details of the tethered agonist mode of activation for the adhesion GPCR ADGRF5/GPR116 To examine this hypothesis, we characterized tethered agonist-mediated activation of GPR116 in vitro A knock-in mouse expressing a non-cleavable GPR116 mutant phenocopies the pulmonary phenotype of GPR116 and recapitulate these findings in a model supporting tethered agonist:ECL2 interactions for GPR116

Signaling by Neutrophil G Protein-Coupled Receptors that Regulate the Release of Superoxide Anions GPR176

GPCRs in Oncology and Immunology GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS

In addition, hearing loss can be caused by mutations of certain GPCRs, such as Vlgr1, Gpr156, S1P2, and Gpr126.

, Demet Araç, et al. for their work on The far extracellular CUB domain of the adhesion GPCR ADGRG6/GPR126 peristalsis and labels tick midgut muscles The far extracellular CUB domain of the adhesion GPCR ADGRG6/GPR126

Adhesion GPCRs Collagen VI Is a Gi-Biased Ligand of the Adhesion GPCR GPR126/ADGRG6.

Let’s dive into the Classified GPCR News from July 8th to 14th, 2024 GPCR Activation and Signaling GPR116

Adhesion GPCRs Adhesion G Protein-Coupled Receptor Gpr126 (Adgrg6) Expression Profiling in Diseased Mouse

accuracy in ligand-bound G protein-coupled receptors Molecular insights into the activation mechanism of GPR156

Adhesion GPCRs A screen of pharmacologically active compounds to identify modulators of the Adgrg6/Gpr126

G-protein-coupled receptor mayo/CG11318 controls midgut development in Drosophila Structure, ligands, and roles of GPR126

A small molecule ligand for the novel pain target, GPR171, produces minimal reward in mice.

Structural and Molecular Insights into GPCR Function Cryo-EM structure of human class C orphan GPCR GPR179

dive into the Classified GPCR News from January 15th to 21st, 2024 Adhesion GPCRs The adhesion GPCR GPR116

Cryo-EM structure of G-protein-coupled receptor GPR17 in complex with inhibitory G protein.