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< GPCR News < GPCRs in Oncology and Immunology GPR176 Promotes Cancer Progression by Interacting with Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer Published date March 11, 2023 Abstract " GPR176 In the present study, expression analyses of GPR176 are performed in patients with colorectal cancer. Genetic mouse models of CRC coupled with Gpr176-deficiency are investigated, and in vivo and in vitro A positive correlation between GPR176 upregulation and the proliferation and poor overall survival of

< GPCR News < GPCRs in Oncology and Immunology GPR176 promotes fibroblast-to-myofibroblast transition Among them, we focused on Gpr176 owing to its significant correlation with a myofibroblast marker α-smooth Furthermore, fibroblasts abundantly expressed Gpr176 compared to alveolar epithelial cells, endothelial of Gpr176 by siRNA reduced TGFβ1-induced expression of αSMA, fibronectin, and collagen as well as Smad2 This suggested that Gpr176 regulates fibroblast activation.

Brendan’s PhD project focuses on the orphan GPCR GPR146. This project aims to characterise the molecular pharmacology of GPR146 and to validate the proposed ligands of GPR146 in line with IUPHAR-NC guidelines on deorphanisation of orphan GPCRs.

System, Proteomics and Transcriptomics, Receptor Structure, Signaling and Activation Mechanism Adgrg6/Gpr126 an alternative promoter in intron 17 Rashed Rezwan Parag Identification of Differentially Expressed Gpr116 Biology Tyler Bernadyn Next Generation MBD2 inhibitors for Brain Cancer Therapy Jesse Stillwell Adgrg6/Gpr126 Rashed Rezwan Parag on the web Google Scholar Identification of Differentially Expressed Gpr116 (Adgrf5 I am researching the physiological relevance of Adgrf5 (Gpr116) transcript variants in specific cell

ADGRG1/GPR56 regulates survival of terminally differentiated CD8+ T cells Cheng-Chih Hsiao Adhesion GPCR GPR116 Researcher associate, Netherlands Brain Bank" Cheng-Chih Hsiao on the web LinkedIn ReseachGate Adhesion GPCR GPR116

glucocorticoid to mediate its rapid actions, the progesterone and 17-hydroxyprogesterone membrane receptor are GPR126

Yuling Feng The ADGRF5/GPR116 receptor is a key regulator of lymphatic endothelial cell identity and Yuling Feng on the web LinkedIn The ADGRF5/GPR116 receptor is a key regulator of lymphatic endothelial

molecular insights into GPCR function December 5, 2024 Molecular insights into the activation mechanism of GPR156

Kordon Deorphanization Of The Adhesion GPCRs GPR110 and GPR116 Tingzhen Shen Self-Cleavage of GPR110 Kordon on the web Araç Laboratory at UChicago Deorphanization Of The Adhesion GPCRs GPR110 and GPR116