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Previous findings suggest that parallel pathways independently relay innate threat signals from different Yet little is known about whether and how multi-sensory innate threat cues are integrated and conveyed The identification of unified innate threat pathways may provide insights into developing therapeutic candidates for innate fear-related disorders."

In this work, we report the subcellular localization of histamine receptor 2 (H2R), a G protein-coupled receptor (GPCR), which is expressed in a wide variety of cell and tissue types. study, for the first time, we demonstrate the nuclear localization of H2R in lymphatic endothelial cells

October 2022 N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of -2 receptor (GLP-2R) antagonists are needed. Experimental approach: COS-7 cells were transfected with the human GLP-2R and assessed for cAMP accumulation or competition binding using 125 I-GLP-2(1-33)[M10Y]. To examine selectivity, COS-7 cells expressing human GLP-1 or GIP receptors were assessed for cAMP accumulation

Immunology CB2 stimulation of adipose resident ILC2s orchestrates immune balance and ameliorates type 2 diabetes mellitus Published date July 3, 2024 Abstract "Development of type 2 diabetes mellitus (T2DM Group 2 innate lymphoid cells (ILC2s) play a critical role in maintaining adipose homeostasis via the production of type 2 cytokines. resistance Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call

and cells that drive neuroimmune activation and sensitization to previously sub-threshold stimuli. Agency , FDA , FcεRIα , FeNO , Fractional exhaled nitric oxide , G-protein-coupled receptor , GPCR , Group 2 innate lymphoid cell , HES , High-affinity Fc receptor for IgE , Hypereosinophilic syndrome , IFNG-AS1 , IRF1 , IgE , Immunoglobulin E , Innate lymphoid cell , Interferon gamma-AS1 , Interferon regulatory cell , TRP , TRPA1 , TRPM4 , TRPM8 , TRPV1 TRPV4 , TSLP , TSLPR , Th2 , Thymic stromal lymphopoietin

Methods: We identified GPCRs expressed in primary CD4+CCR5+ T cells by multi-RT-qPCR. Cell lines expressing EBI2 were established by transduction with HIV vectors. The amount of HIV reverse transcripts was similar in cells expressing or not EBI2. As the natural ligand for EBI2 is present in blood and lymphoid tissues, the constant EBI2 activation might increase HIV replication in CD4+ T cells.