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September 2022 Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism , microbiota, and T cell-induced inflammation "Gut intraepithelial lymphocytes (IELs) are thought to Here, we show that the gut IEL GLP-1 receptor (GLP-1R) is not required for enteroendocrine L cell GLP Instead, the gut IEL GLP-1R is essential for the full effects of GLP-1RAs on gut microbiota. activation in gut IELs to modulation of microbiota composition and control of intestinal and systemic

October 2022 N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of interaction "Background and purpose: To fully elucidate the regulatory role of the GLP-2 system in the gut

GPCR drug discovery via multitask learning GPCRs in Cardiology, Endocrinology, and Taste The Role of Gut Microbiota and Associated Compounds in Cardiovascular Health and its Therapeutic Implications The perspective

Recent studies have demonstrated that small-molecules from gut microbiota act as ligands for specific inferred the most predominant GPCR-mediated microbial metabolite-human cell interactions regulating gut-immune-brain and metabolite cataloging with mechanistic studies for an improved understanding of gut microbiota-immune-brain Authors Gajender Aleti , Emily A Troyer , Suzi Hong Tags G protein-coupled receptors , Gut microbiota , Human-microbiota interactions , Immune system , Inflammation , Metabolites Source Contribute to the

Oncology and Immunology High Metabolite Concentrations in Portal Venous Blood as a Possible Mechanism for Microbiota the Immune System, and Western Diseases Published date November 20, 2023 Abstract "We show that the gut This model helps explain how the gut microbiome may be affecting peripheral immune cells, and consequently Western lifestyle diseases, most of which are immune based, in tissues remote from the gut." Authors Quanbo Wang , Charles R Mackay Tags Gut microbiota , Western lifestyle diseases , portal vein

Published date December 4, 2024 Abstract "Short-chain fatty acids (SCFAs), derived from the diet and the microbiota , serve as crucial links between the diet, gut microbiota, metabolism, immunity, and cancer.