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September 2022 Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism , microbiota, and T cell-induced inflammation "Gut intraepithelial lymphocytes (IELs) are thought to Here, we show that the gut IEL GLP-1 receptor (GLP-1R) is not required for enteroendocrine L cell GLP Instead, the gut IEL GLP-1R is essential for the full effects of GLP-1RAs on gut microbiota. activation in gut IELs to modulation of microbiota composition and control of intestinal and systemic

October 2022 N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of interaction "Background and purpose: To fully elucidate the regulatory role of the GLP-2 system in the gut

GPCR drug discovery via multitask learning GPCRs in Cardiology, Endocrinology, and Taste The Role of Gut Microbiota and Associated Compounds in Cardiovascular Health and its Therapeutic Implications The perspective

receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection "Healthy skin maintains a diverse microbiome This signaling axis was required for effective neutrophil-mediated skin immunity and microbiome homeostasis

drug discovery programs in key therapeutic areas Kallyope, pioneers in drug discovery involving the gut-brain biopharmaceutical company, and New York City-based Kallyope, pioneers in drug discovery involving the gut-brain

of GPR84 may potentially prove effective also in diseases associated with inflammation of the lower gut

regulation of metabolic processes in adipose tissue, liver, pancreas, adrenal, skeletal muscle, and gut

on ultrahigh-throughput technologies that biomine drug-like molecules from natural sources, such as microbiota

However, only a small fraction of these metabolites has been identified from the human microbiota thus

manipulates neuroactive signals and may onset metabolic disturbances GPCR Binders, Drugs, and more Gut

Recent studies revealed butyrate and secondary bile acids, produced by the intestinal microbiome, potentiate We now aim to determine the molecular mechanism by which this functional microbiome output regulates

Modulation of GPCR receptors common to gut inflammatory diseases and neuronal disorders, Alzheimer's

Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions

in models of autism spectrum disorders Systematic characterization of multi-omics landscape between gut

cascade that results in enhanced serotonin release (Braun T. et. al 2007), an important regulator of gut

microenvironment High Metabolite Concentrations in Portal Venous Blood as a Possible Mechanism for Microbiota

immunodeficiency G protein-coupled receptors: A target for microbial metabolites and a mechanistic link to microbiome-immune-brain