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Recent studies have demonstrated that small-molecules from gut microbiota act as ligands for specific inferred the most predominant GPCR-mediated microbial metabolite-human cell interactions regulating gut-immune-brain and metabolite cataloging with mechanistic studies for an improved understanding of gut microbiota-immune-brain Authors Gajender Aleti , Emily A Troyer , Suzi Hong Tags G protein-coupled receptors , Gut microbiota , Human-microbiota interactions , Immune system , Inflammation , Metabolites Source Contribute to the

Oncology and Immunology High Metabolite Concentrations in Portal Venous Blood as a Possible Mechanism for Microbiota the Immune System, and Western Diseases Published date November 20, 2023 Abstract "We show that the gut This model helps explain how the gut microbiome may be affecting peripheral immune cells, and consequently Western lifestyle diseases, most of which are immune based, in tissues remote from the gut." Authors Quanbo Wang , Charles R Mackay Tags Gut microbiota , Western lifestyle diseases , portal vein

Published date December 4, 2024 Abstract "Short-chain fatty acids (SCFAs), derived from the diet and the microbiota , serve as crucial links between the diet, gut microbiota, metabolism, immunity, and cancer.

Published date May 21, 2024 Abstract "Inflammatory bowel disease (IBD) is characterized by dysbiosis of the gut microbiota and dysfunction of intestinal stem cells (ISCs).

Indeed, gut microbiota dysbiosis and metabolomic profile alterations, are hallmarks of IBD. The aim of this study was to characterize the axis microbiota-metabolite-GPCR in intestinal surgical Results showed that UC patients had a lower microbiota richness and bacterial load, with a higher proportion Barrachina, Jesús Cosín-Roger Tags GPR109A , IBD , Metabolite-sensing GPCRs , Metabolomic alterations , Microbiota

I am now working at the Cleveland Clinic in Ohio, USA, studying the gut microbiome and its impact on My research goal is to identify novel cellular target receptors of human gut microbe-derived metabolites During my post-doctoral research, I was part of a study that identified the receptors of a novel human gut study, I discovered adrenergic receptors (α2A, α2B, and β2-adrenergic receptors) that serve as the gut

discussed the challenges of studying metabolites and their receptors, the relationship between metabolites, gut Metabolites, Gut Health, and Disease Progression Yamina and Claudia had a discussion about the relationship between metabolites, gut health, and disease progression. Yamina proposed that the metabolites in the gut of a non-healthy person might be different from those Claudia agreed, suggesting that the complexity of the gut microbiome is akin to a "complicated city vicus

pathophysiological systems, with particular focus on women's health, pregnancy, and nutrient sensing in the gut

pathophysiological systems, with particular focus on women's health, pregnancy, and nutrient sensing in the gut