Oncogenic Potential and Is Markedly Upregulated in Hepatocellular Carcinoma "Hepatocellular carcinoma (HCC ) is at the forefront of the global cancer burden, and biomarkers for HCC are constantly being sought role of RGS20 as a potential prognostic marker in 28 different cancer types with special emphasis on HCC patients; (c) besides HCC (p < 0.001), RGS20 was found to be an important factor for survival in four potential and is markedly upregulated in HCC patients.

Our previous study indicated that ARBB1 (arrestin beta 1) promotes hepatocellular carcinogenesis (HCC However, the role of ARRB1 in HBx-related HCC remains unclear. Our results demonstrate that ARRB1 plays a critical role in HBV-related HCC via modulating autophagy and the CDKN1B-CDK2-CCNE1-E2F1 axis and indicate that ARRB1 may be a potential therapeutic target for HCC.Abbreviations factor 1; FBS: fetal bovine serum; GPCRs: G protein-coupled receptors; GST: glutathione S-transferase; HCC

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