Magdalena M Scharf, Antonella Di Pizio, Ines Liebscher, Hannes Schihada, and Gunnar Schulte et al. on

Hannes Schihada and his lab team developed fluorescent analogues for real-time binding studies of orphan

Today is also the first session of our hands-on workshop with Dr. Sam Hoare.

associate with the active parathyroid hormone 1 receptor (PTH1R) in different complex configurations ("hanging

January 2022 "Voltaire argued, “Perfection is attained by slow degrees; it requires the hand of time

The drugs also target relatively low-hanging fruit: like cytokines or tyrosine kinase receptors.

On the other hand, they showed the ability to couple with Gαq/11 protein and make Ca2+ mobilization at

GPCR University hands-on workshop with Dr.  Sam Hoare about this hands-on workshop HERE ⬇⬇⬇ Dr.

(TMD), with the most compelling studies revealing that the transmembrane helices TM4 and TM5 on one hand , and TM1 and TM7 on the other hand, form possible dimerization interfaces (Ploier, B. et al. 2016; Dijkman

GPCR University hands-on workshop with Dr.  Sam Hoare about this hands-on workshop HERE ⬇⬇⬇ Dr.

On the other hand, selectivity could be achieved by merging both orthosteric and allosteric pharmacophores On the other hand, positive allosteric modulators that target intracellular allosteric sites can enhance

On the other hand, RTKs play pivotal roles in growth factor signaling, regulating cell growth, differentiation

GPCR University hands-on workshop with Dr. 

Loan Facility with Hercules Capital Gene-to-structure and Europe give Proteros customers a winning hand

GPCR University hands-on workshop with Dr. 

On the other hand, Shall and Proudfoot excluded the idea of molecular redundancy, pointing out that,

On the other hand, selectivity could be achieved by merging both orthosteric and allosteric pharmacophores

GPCR University hands-on workshop with Dr. 

unsupervised machine learning: most applications of ML in GPCR drug discovery have relied on traditional, hand-crafted

Cryo-EM, on the other hand, requires less protein and has evolved to achieve resolutions comparable to

However, the receptors that these medicines target have been described as the ‘low-hanging’ fruit, and