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Despite major advances in the field of pharmacological CVD treatments, particularly in the field of heart failure (HF) research, case numbers and overall mortality remain high and have trended upwards over differential domains of GRK2 to modulate both beneficial and deleterious signaling pathways in the heart

events driving the fibrotic response and the communications between fibroblasts and other cells in the heart

October 2022 "Systolic heart failure (HF) is a chronic clinical syndrome characterized by the reduction alterations that confer significant hormonal burden on the already compromised function of the failing heart receptor antagonists, which block the effects of angiotensin II (AngII) and aldosterone on the failing heart

β-arrestin2 play multiple roles in the pathological mechanisms of a wide range of diseases including heart failure, cancer, and inflammatory diseases.

on their work entitled β-arrestins and their potential role in heart failure. Dr. inflammatory diseases β-adrenergic receptor signaling mediated by β-arrestins and its potential role in heart failure GPCRs in Neuroscience Role of lipids in the control of autophagy and primary cilium signaling

Biased Signal Transduction Pathways Activation of a GPCR, ORL1 receptor: A novel therapy to prevent heart failure progression GPCR Binders, Drugs, and more Advances in GPCR-targeted drug development in dermatology

as Collaboration Targeting Neurological Diseases Achieves First R&D Milestone Tectonic bets on GPCR heart failure drug following reverse merger with Avrobio Lilly signs $140M upfront partnership with Radionetics

GPCRs in Cardiology, Endocrinology, and Taste Targeting G Protein-Coupled Receptors for Heart Failure

and Taste α1-Adrenergic Receptors: Insights into Potential Therapeutic Opportunities for COVID-19, Heart Failure, and Alzheimer's Disease.

synergistic membrane-to-nucleus information transfer TMC6 functions as a GPCR-like receptor to sense noxious heat Monlunabant by Inversago Pharma for Metabolic Syndrome: Likelihood of Approval Tectonic bets on GPCR heart failure drug following reverse merger with Avrobio Addex Pharma unveils new mGlu7 receptor negative

metabolic diseases: pharmacotherapeutic development updates Targeting G protein-coupled receptors for heart failure treatment RAMP and MRAP accessory proteins have selective effects on expression and signalling

cardiomyocyte-specific Adhesion G Protein Coupled Receptor G1 (ADGRG1/GPR56) promotes pressure overload-induced heart failure GPCR Activation and Signaling Positive allosteric modulation of a GPCR ternary complex GPCR

Receptor autoantibodies: Associations with cardiac markers, histology, and function in human non-ischaemic heart failure.

Receptor autoantibodies: Associations with cardiac markers, histology, and function in human non-ischaemic heart failure.

in the cochlea into electrical signals, which are transmitted by spiral ganglion neurons (SGNs) and heard disorders, and the treatment for hearing loss. In addition, hearing loss can be caused by mutations of certain GPCRs, such as Vlgr1, Gpr156, S1P2, and And A1, A2A, and CB2 activation by agonists has protective functions on noise- or drug-induced hearing loss, and hearing protection."

August 2022 "The calcium-permeable cation channel TRPM3 can be activated by heat and the endogenous steroid TRPM3's best understood function is its role as a peripheral noxious heat sensor in mice.

The event will take place in the heart of Leipzig, which offers a colorful mixture of culture and vivid

In fact, it is often costly, frustrating, and tortuous—and more often than not it ends in failure.

The event will take place in the heart of Leipzig, which offers a colorful mixture of culture and vivid

Propranolol, initially prescribed for high blood pressure, irregular heart rate, essential tremor, and

TGR5 is widely distributed in the brain, lung, heart, liver, spleen, pancreas, kidney, stomach, jejunum

Many cause receptor misfolding and failure to reach the cell surface.

pathways, are leading to the development of drugs with superior efficacy and reduced side effects in heart

development of databases supporting medical research ‘Define your own success’: Duke leaders talk success, failure

and Immunology The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure

The Importance of Experimental Controls Experiments are at the heart of a PhD in the sciences, and one

GPCRs in Oncology and Immunology A GPCR checkpoint drives CD8+ T cell dysfunction and immunotherapy failure

Immunology and Oncology The GPCR–Gαs–PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure