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376 items found for "Helen Su"
- 📢 Early Bird Registration Ends Tomorrow! | Sep 16 - 22, 2024
Highlights: Celebrating Excellence: Hyoungjun Ham , Yamina Berchiche , Thomas Sakmar , Vladimir Katanaev , Helen Su , et al. for their fantastic work on Germline mutations in a G protein identify signaling cross-talk Mark your calendars and make sure to enroll before the deadline! agonist ZT-003 shows promising results for metabolic disorders INDIGO Biosciences, INC as a Preferred Supplier 27, 2024 | 1st Virtual GPCR Forum Conference November 26 - 28, 2024 | GPCRs-Targeted Drug Discovery Summit
- Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist...
October 2022 Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered autocatalytic cleavage upstream of the agonistic peptide sequence, an event necessary for NTF displacement and subsequent mediate stronger signaling in mouse versus human GPR116 and recapitulate these findings in a model supporting
- GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates axonal...
August 2022 GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates The axonal degeneration that occurs before retinal ganglion neuronal loss is suggested to be involved Our earlier reports suggested that GPR3 enhances both neurite outgrowth and neuronal survival. Surprisingly, RGCs in GPR3 knockout mice were vulnerable to neural death during aging without affecting These results suggest that GPR3 expression in RGCs helps maintain neuronal survival and accelerates axonal
- Glyco-sulfo hotspots in the chemokine receptor system
Glycosylation and sulfation – N-terminal PTMs on chemokine receptors The interaction of chemokine receptors N-terminal PTMs include sulfation and glycosylation which contribute to the overall negative charge of tool for tyrosine sulfation sites (Monigatti F et al. 2002), suggest that CC chemokine receptors have Tyrosine sulfation consists in the transfer of a sulfate group from the adenosine 3’-phosphate 5’-phosphosulfate There are few examples of the applicability of the sulfo-glyco barcode in drug discovery.
- Dimerization of β2-adrenergic receptor is responsible for the constitutive activity subjected to inv
Read more at the source #DrGPCR #GPCR #IndustryNews Subscribe to the Dr. GPCR Newsletter HERE
- Dimerization of β2-adrenergic receptor is responsible for the constitutive activity subjected to...
October 2022 Dimerization of β2-adrenergic receptor is responsible for the constitutive activity subjected Read more at the source #DrGPCR #GPCR #IndustryNews Subscribe to the Dr. GPCR Newsletter
- Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and...
October 2022 Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and This study unveiled a new antifibrotic cGAS/STING signaling pathway that suppresses pathological angiogenesis We showed that cGAS expression was induced in fibrotic liver and kidney, but suppressed in endothelial Together, our data support that activation of cGAS/STING signaling mitigates organ fibrosis and suppresses
- Successful prednisolone or calcimimetic treatment of acquired hypocalciuric hypercalcemia caused...
October 2022 Successful prednisolone or calcimimetic treatment of acquired hypocalciuric hypercalcemia This emphasizes the importance of the Gi/o (pertussis toxin-sensitive G proteins, whose βγ subunits activate fluctuating Ca levels from approximately normal to near fatally high ranges, (e) acute exacerbations could be successfully
- TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory...
August 2022 TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory
- In vitro assays for the functional characterization of (psychedelic) substances at the serotonin...
August 2022 In vitro assays for the functional characterization of (psychedelic) substances at the serotonin receptor 5-HT2A R "Serotonergic psychedelics are substances that induce alterations in mood, perception Besides their appearance on the (illicit) drug market, e.g. as new psychoactive substances, their potential This group of substances demonstrates a broad structural variety, leading to insufficiently described
- Opioid Ligands Addressing Unconventional Binding Sites and More Than One Opioid Receptor Subtype
is, besides classical ligands, a great number of bivalent ligands (i. e. aiming on two distinct OR subtypes
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GPCR Summit 2022 is less than a month away! Come live and breathe GPCRs with us and don’t forget to submit your abstract.
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GPCR Summit 2022 held between Oct. 10 - 16, it's FREE! Join the #GPCR movement by signing up now!
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👥We have many surprises in reserve for you at the next Dr. GPCR Summit 2022 held between October 10th and 16th. Dr. GPCR Summit is FREE for all Ecosystem site members! Become a member today, it's also free!
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GPCR event of the year is the 3rd edition of the Summit. GPCR Ecosystem site member to attend the Summit, it’s free! ➡️ https://bit.ly/3SUkB8D #gpcr #drgpcr
- Regulation of rod photoreceptor function by farnesylated G-protein γ-subunits
Despite similar subunit composition, close amino acid identity, and identical posttranslational farnesylation of their Gγ subunits, rods and cones rely on unique Gγ1 ( Gngt1 ) and Gγc ( Gngt2 ) isoforms, respectively The only other farnesylated G-protein γ-subunit, Gγ11 ( Gng11 ), is expressed in multiple tissues but Thus, while farnesylated Gγ subunits are functionally active and largely interchangeable in supporting
- Cell Surface Calcium-Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca 2+ Sensing but...
September 2022 Cell Surface Calcium-Sensing Receptor Heterodimers: Mutant Gene Dosage Affects Ca 2+ Sensing Herein we generated CaSR-GABAB1 and CaSR-GABAB2 chimeras subject to GABAB -dependent endoplasmic reticulum sorting to traffic mutant heterodimers to the cell surface. domain, however, corresponding to heterozygous familial hypocalciuric hypercalcemia type-1 (FHH-1), supported We consider how receptor asymmetry may support the underlying mechanisms. © 2022 The Authors.
- Fly casting with ligand sliding and orientational selection supporting complex formation of a GPCR..
September 2022 Fly casting with ligand sliding and orientational selection supporting complex formation
- Identification and functional characterization of the sulfakinin and sulfakinin receptor in the...
September 2022 Identification and functional characterization of the sulfakinin and sulfakinin receptor in the Chinese white pine beetle Dendroctonus armandi "The sulfakinin (SK) is an important signal molecule
- Identification of hub genes in the subacute spinal cord injury in rats
Subacute SCI is mainly characterized by neuronal apoptosis, axonal demyelination, Wallerian degeneration It has been discovered in recent years that inflammatory responses are particularly important in subacute
- Dr. GPCR Summit 2022 is coming!
GPCR Summit is between October 10th to the 16th! participate by presenting a trainee talk, a poster, or a pre-recorded talk Become a site member for FREE and submit ➡️ https://www.ecosystem.drgpcr.com/dr-gpcr-summit-2022 #gpcr #drgpcr
- ShouTi Introduces Basecamp Bio as a Wholly Owned Subsidiary to Expand Pipeline and Partnerships
therapeutics to treat a wide range of chronic diseases, today introduced Basecamp Bio, a wholly owned subsidiary
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GPCR Summit is totally FREE for our Ecosystem site members?
- Confo Therapeutics Doses First Subjects In Phase 1 Clinical Trial Of CFTX-1554 For The Treatment ...
March 2022 Confo Therapeutics Doses First Subjects In Phase 1 Clinical Trial Of CFTX-1554 For The Treatment discovery of medicines targeting G-protein coupled receptors (GPCRs), today announced that the first subjects The Phase 1 study will assess the safety, tolerability and pharmacokinetics of CFTX-1554 in healthy subjects
- Trevena Announce Submission of New Drug Application in China for OLINVYK® by its Partner Jiangsu ...
February 2022 Trevena Announces Submission of New Drug Application in China for OLINVYK® by its Partner Jiangsu Nhwa Pharmaceutical "Submission supported by data from a Phase 3 bridging study of oliceridine injection compared to IV morphine, conducted in China by Nhwa Trevena is eligible to receive future success disorders, today announced that China’s National Medical Products Administration (NMPA) has accepted submission The NDA was submitted by Trevena’s partner, Jiangsu Nhwa Pharmaceutical, and follows completion by Nhwa
- Synaptic integration of subquantal neurotransmission by co-localized G protein coupled receptors in
At CA1-subicular presynaptic terminals 5-HT1B and GABAB receptors colocalize.