Our earlier transcriptomic analysis identified Urothelial Carcinoma Associated-1 (UCA1) as an LPA-stimulated elevated expression of UCA1 enhances cell proliferation, invasive migration, and therapy resistance in high-grade serous ovarian carcinoma cells, whereas silencing UCA1 reverses these oncogenic phenotypes. Bhattacharya , Priyabrata Mukherjee , Ciro Isidoro , Yong Sang Song , Danny N Dhanasekaran Tags GPCR , High Grade Serous Ovarian Carcinoma , Let-7 miRNAs , Oncogenic Pathways , Ovarian Cancer , Therapy Resistance

overexpression of protease-activated receptor 2 (PAR2), a GPCR member in the fallopian tubes (FTs) of high-risk FTs, the origin of ovarian cancer, are known to express genes of serous tubal intraepithelial carcinoma (STICs), a precursor lesion of high-grade serous carcinoma (HGSC). PAR2 expression in FTs may serve as an early prediction sensor for ovarian cancer. serve as a powerful medicament in STICs and ovarian cancer.

Oncology and Immunology PAXIP1-AS1 is associated with immune infiltration and predicts poor prognosis in ovarian OC tissues were collected from The Cancer Genome Atlas (TCGA) database. 427 OC tissues and 88 normal ovarian Low PAXIP1-AS1 expression in OC was associated with age (P = 0.045), histological grade (P = 0.011), pathway, and Focal Adhesion-PI3K-Akt-mTOR-signaling pathway were differentially enriched in PAXIP1-AS1 high There were some genomic variations between the PAXIP1-AS1 high and low expression groups.

News < GPCRs in Oncology and Immunology Unveiling G-protein coupled receptors as potential targets for ovarian data analysis to in vitro validation Published date July 27, 2024 Abstract "Genetic heterogeneity in ovarian To address the genetic heterogeneity of ovarian cancer, a future personalised approach could include Subsequently, primary ovarian cancer cells derived from ascites and ovarian cancer cell lines were used However, the expression levels showed high variability within our selection of samples, therefore, supporting

Program < Back to schedule Inhibition of Relaxin Autocrine Signaling Confers Therapeutic Vulnerability in Ovarian He has focussed on developing a comprehensive map of ovarian cancer essential genes using whole genome provided insight into novel drivers resulting from the widespread gene copy number aberrations observed in ovarian Several of these targets are being developed for potential new therapeutic strategies in ovarian and

coupled receptor-related gene signature through bioinformatics analysis to construct a risk model for ovarian cancer prognosis Published date June 18, 2024 Abstract " Background: Ovarian cancer (OV) is a common The immunological characteristics of the high- and low-risk groups were analyzed using single-sample K-M analysis of the prognostic model showed that it could differentiate high- and low-risk patients, Yongmei Li, Chunfang Ha Tags G protein-coupled receptor , Immune infiltration , Molecular marker , Ovarian

Immunology Metallo-protease Peptidase M84 from Bacillusaltitudinis induces ROS-dependent apoptosis in ovarian metallo-protease had no discernible impact on normal cell survival, but it specifically induced apoptosis in ovarian PAR-1, a GPCR which is reported to be overexpressed in ovarian cancer cells, was identified as a target This evoked apoptotic death of the ovarian cancer cells through the intrinsic route. This established Peptidase M84 as a drug candidate for receptor mediated targeted-therapy of ovarian

< GPCR News < GPCRs in Oncology and Immunology NPFF stimulates human ovarian cancer cell invasion by Epithelial ovarian cancer (EOC) is a leading cause of death among gynecological malignancies. Lanlan Fang , Peter C K Leung , Jung-Chien Cheng Tags Invasion , MMP-9 , NPFFR2 , Neuropeptide FF , Ovarian

< GPCR News < GPCRs in Oncology and Immunology Ovarian cancer G protein-coupled receptor 1 (OGR1) deficiency crystalline nephropathy by increasing the oxalate intake of GPR4 KO and OGR1 KO mice.  After 10 days of high-oxalate

< GPCR News < GPCRs in Oncology and Immunology High expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma cells in vitro Published date June 26, 2023 Abstract "G protein-coupled receptors (GPCRs) play important roles in tumorigenesis and the development of hepatocellular carcinoma

and Immunology SSTR2 positively associates with EGFR and predicts poor prognosis in nasopharyngeal carcinoma biological functions in humans, and it is upregulated through the NF-KB signalling pathway in nasopharyngeal carcinomas The study found that patients receiving chemoradiotherapy (CR) with high expression of SSTR2, high expression Interestingly, NPC patients with high expression of SSTR2, high expression of EGFR, high coexpression of EGFR and SSTR2, and EGFR/SSTR2 anyone high expression had a better prognosis with CR combined with

Immunology Expression pattern and clinical significance of beta 2-adrenergic receptor in oral squamous cell carcinoma significance in relation with the clinicopathological features and overall survival of oral squamous cell carcinoma Results: Out of the total of 65 OSCC tissues, 41 tissues (63.1%) exhibited high expression for β2-AR High β2-AR protein expression was significantly associated with multiple risk habits (p = 0.045), histological AR protein level is identified as an independent significant prognostic factor in patients with oral carcinoma

visualized in recent years due to their contribution to the progression of cancers, such as prostate and ovarian stages, our efforts should focus on early diagnosis, validating for example specific KLKs, especially in high-risk

GPCRs in Oncology and Immunology Exploration of prognostic and treatment markers in hepatocellular carcinoma In this study, the role of GPCRs in hepatocellular carcinoma (HCC) was elucidated, and GPCR-related genes Methods: Patients' data on HCC were sourced from the Liver Hepatocellular Carcinoma-Japan (LIRI-JP) and In addition, patients were classified into groups with high and low risks. Patients in the high-risk group exhibited a worse prognosis but demonstrated a more favorable immunotherapy

analog extended with an N-terminal D-lysine, impairs growth of patient-derived xenografts of colorectal carcinoma Consistent with its high specificity and stability, LP2 has shown excellent safety and pharmacokinetics subcutaneously injected dose as low as 0.2 µg/kg/day inhibited patient-derived xenografts of colorectal carcinoma

of receptors expression dynamics was performed for tumor-nodes-metastases (TNM) defined subgroups (ovarian

several types of cancer and has been shown to be overexpressed in prostate, breast, pancreatic, and ovarian

While the prognosis of colorectal carcinoma (CRC) is better than that of PDAC, it still is the second-leading Consistent with GAL2 receptor-mediated tumor inhibition, for PDAC, survival is much higher for patients with high

< GPCR News < GPCRs in Oncology and Immunology High Metabolite Concentrations in Portal Venous Blood show that the gut bacterial metabolites, short chain fatty acids (SCFAs), are present at exceptionally high Likely, many other metabolites will be present at high concentrations.

mRNA expression and/or VIPR2 gene copy number has been documented in several cancers including breast carcinoma /ERK signaling pathway, and the excessive expression of VIPR2 may lead to an exacerbation of breast carcinoma

< GPCR News < GPCRs in Oncology and Immunology Phase 1/2 study of sorafenib added to cladribine, high-dose

GPCR News < GPCRs in Oncology and Immunology miR-19a may function as a biomarker of oral squamous cell carcinoma

< GPCR News < GPCRs in Oncology and Immunology RGS20 promotes non-small cell lung carcinoma proliferation

Ductal carcinomas are increasingly diagnosed but identifying which will progress to invasive disease remains difficult highlighting an urgent need for new biomarkers that distinguish ductal carcinomas on CELSR1 is reactivated in luminal-type ductal carcinomas. Notably, our pilot data from luminal-type breast cancer cell lines representative of breast carcinomas invasive mechanism (b) quantify CELSR1 isoform expression (mRNA and protein) within patient luminal carcinoma

type specific expression of TACR3 in response to renal injury and expressional dynamics during renal carcinoma

Thursday, November 2nd / 1:45 PM - 2:45 PM Trainee Symposium I Eric Johansen , Johns Hopkins University Grace November 3rd / 3:55 PM Inhibition of Relaxin Autocrine Signaling Confers Therapeutic Vulnerability in Ovarian

SSTR5 in pituitary corticotroph tumours; GLP1R, GIPR, and somatostatin receptors in medullary thyroid carcinoma

May 30, 2023 Abstract "Background: Neuropeptide Y (NPY) is an abundant neurohormone in human breast carcinomas