Samuel Hoare on Advanced data analysis for GPCR pharmacology, which will be held on Thursdays between Hoare, according to his availability Access to the cohort’s Dr. Hoare and your classmates Access to the course materials and recordings once the course is completed Hoare and Dr. GPCR Complementary one-year Dr. Hoare's workshop for individuals who live and work in developing countries.

Hoare's workshop for individuals who live and work in developing countries.  Samuel Hoare on Advanced data analysis for GPCR pharmacology, which will be held on Thursdays between The workshop includes: Four x 2-hour Zoom sessions One-on-one meeting with Dr. Hoare Access to Dr. Sam Hoare about this hands-on workshop HERE ⬇⬇⬇ Dr.

Samuel Hoare on Advanced data analysis for GPCR pharmacology, which will be held on Thursdays between The workshop includes: Four x 2-hour Zoom sessions One-on-one meeting with Dr. Hoare Access to Dr. Hoare's workshop for individuals who live and work in developing countries. Sam Hoare about this hands-on workshop HERE ⬇⬇⬇ Dr.

Samuel Hoare on Advanced data analysis for GPCR pharmacology, which will be held on Thursdays between The workshop includes: Four x 2-hour Zoom sessions One-on-one meeting with Dr. Hoare Access to Dr. Hoare's workshop for individuals who live and work in developing countries.

Sam Hoare. If you aren't joining us this time, stay tuned for more Dr.

Hoare's workshop for individuals who live and work in developing countries.  Samuel Hoare on Advanced data analysis for GPCR pharmacology, which will be held on Thursdays between The workshop includes: Four x 2-hour Zoom sessions One-on-one meeting with Dr. Hoare Access to Dr.

Samuel Hoare / Pharmechanics. Get your ticket now!

Sam Hoare as our instructor. Gain invaluable skills in data analysis under Dr. Hoare's expert guidance. More details are coming soon—stay tuned! Dr.

Sam Hoare as our instructor. Under Dr. Hoare's expert guidance, you will gain invaluable skills in data analysis.

Sam Hoare as our instructor. With Dr. Hoare, you’ll learn how to analyze your data like a pro.

Kenakin and Hoare .

Kenakin and Hoare.

Kenakin and Hoare on '   Applying Pharmacology to Drug Discovery ' and ' Advanced Data Analysis for GPCR

Sam Hoare. It's been a remarkable experience with participants joining us from around the globe.

Terry Kenakin  and Sam Hoare ! Registration Closes Tomorrow!

The research of GPCRs in the cochlea is essential for the understanding of the cochlea development, hearing disorders, and the treatment for hearing loss. In addition, hearing loss can be caused by mutations of certain GPCRs, such as Vlgr1, Gpr156, S1P2, and And A1, A2A, and CB2 activation by agonists has protective functions on noise- or drug-induced hearing loss, and hearing protection."

Sam Hoare three weeks ago, and it's been fantastic with all the participants from across the world.

Terry Kenakin  and Sam Hoare !

Terry Kenakin and Sam Hoare !

Sam Hoare. Mark your calendar for September and October 2024. Dr. GPCR, hear anecdotes, and get important announcements.

Terry Kenakin and Sam Hoare !

September 2022 "G-protein-coupled receptors (GPCRs) are involved in a wide array of physiological and disease functions, yet knowledge of their role in colon cancer stem cell maintenance is still lacking. In addition, the molecular mechanisms underlying GPCR-induced post-translational signaling regulation are poorly understood. Here, we find that protease-activated receptor 4 (PAR4) unexpectedly acts as a potent oncogene, inducing β-catenin stability and transcriptional activity. Both PAR4 and PAR2 are able to drive the association of methyltransferase EZH2 with β-catenin, culminating in β-catenin methylation. This methylation on a lysine residue at the N-terminal portion of β-catenin suppresses the ubiquitination of β-catenin, thereby promoting PAR-induced β-catenin stability and transcriptional activity. Indeed, EZH2 is found to be directly correlated with high PAR4-driven tumors, and is abundantly expressed in large tumors, whereas very little to almost none is expressed in small tumors. A truncated form of β-catenin, ∆N133β-catenin, devoid of lysine, as well as serine/threonine residues, exhibits low levels of β-catenin and a markedly reduced transcriptional activity following PAR4 activation, in contrast to wt β-catenin. Our study demonstrates the importance of β-catenin lysine methylation in terms of its sustained expression and function. Taken together, we reveal that PAR-induced post-transcriptional regulation of β-catenin is centrally involved in colon cancer." Read more at the source #DrGPCR #GPCR #IndustryNews

Come join us from October 10 to 16 to hear about exciting #GPCR research from amazing speakers.

🎧Hear Dr.

Hear the story from our colleagues in this video."

Excited to hear Dr.

Excited to hear Dr.

Hear the story from our colleagues in this video."