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lipopolysaccharide, the main component of the Gram-negative bacteria cell wall, disrupt not only the hypothalamic–pituitary–adrenal axis but also affects other endocrine systems such as the hypothalamic–pituitary–gonadal axis and the

several important neurohormonal perturbations, emanating from both the autonomic nervous system and the adrenal The adrenal gland plays an important role in the modulation of cardiac neurohormonal stress because it Synthesis and release of these hormones in the adrenals is tightly regulated by adrenal G protein-coupled In this review, we discuss important aspects of adrenal GPCR signaling and regulation, as they pertain to modulation of cardiac function in the context of chronic HF, by focusing on the 2 best studied adrenal

2022 Neurocrine Biosciences Presents Data on Treatment of Adolescent Patients with Classic Congenital Adrenal present new Phase 2 data on the use of crinecerfont in adolescent patients with classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD), which demonstrated substantial reductions in adrenal

medullary axis and the hypothalamic‒pituitary‒adrenal (HPA) axis. Second, the differential regulation of the gene network between the sympathetic-adrenal medullary axis Disruption of the connection between the hypothalamus and the adrenal glands causes autonomous regulation Cheng , De-Zhi Lu , Shuai Fan , Ke-Xin Wang , Li-Li Xu , Bin Cai , Mou-Wang Zhou , Jin-Wu Wang Tags Hypothalamo-pituitary-adrenal axis , Neuroendocrine immunomodulatory axis , Neuroinflammation , SCI-induced immunodeficiency syndrome

GPCRs in Oncology and Immunology Proteogenomic landscape and clinical characterization of GH-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors Published date November 1, 2022 Abstract The clinical characteristics of growth hormone (GH)-producing pituitary adenomas/somatotroph pituitary neuroendocrine

receptor (GPCR) expression is highly prevalent in cortisol-secreting primary bilateral macronodular adrenal GCGR, LHCGR, and 5-HT4R in phaeochromocytomas and paragangliomas; TRHR, GnRHR, GIPR, and GRP101 in pituitary somatotroph tumours; AVPR2, D2DR, and SSTR5 in pituitary corticotroph tumours; GLP1R, GIPR, and somatostatin show that the regulation of endocrine tumours by aberrant GPCR is not restricted to cortisol-secreting adrenal