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lipopolysaccharide, the main component of the Gram-negative bacteria cell wall, disrupt not only the hypothalamic–pituitary–adrenal axis but also affects other endocrine systems such as the hypothalamic–pituitary–gonadal axis and the

several important neurohormonal perturbations, emanating from both the autonomic nervous system and the adrenal The adrenal gland plays an important role in the modulation of cardiac neurohormonal stress because it Synthesis and release of these hormones in the adrenals is tightly regulated by adrenal G protein-coupled In this review, we discuss important aspects of adrenal GPCR signaling and regulation, as they pertain to modulation of cardiac function in the context of chronic HF, by focusing on the 2 best studied adrenal

2022 Neurocrine Biosciences Presents Data on Treatment of Adolescent Patients with Classic Congenital Adrenal present new Phase 2 data on the use of crinecerfont in adolescent patients with classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD), which demonstrated substantial reductions in adrenal

October 2022 Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and Further, pharmacological targeting of cGAS/STING-YAP axis exhibits the potential to alleviate liver and

Reviews, GPCRs, and more Restoring function to inactivating G protein-coupled receptor variants in the hypothalamic-pituitary-gonadal axis1 A novel function of the M2 muscarinic receptor A2B adenosine receptor signaling and regulation Findings at ENDO 2024 for Atumelnant in Two Ongoing, Open-Label Studies for the Treatment of Congenital Adrenal

system in the European sea bass, Dicentrarchus labrax, which exerted an inhibitory action on the brain-pituitary-gonadal axis of this species.

Somatostatin receptors (SSTs) are class A GPCRs abundantly expressed in pituitary tumors where they represent both somatostatin receptor type 2 (SST2) and 5 (SST5) and regulates their expression and signaling in pituitary So far, the existence and physiological relevance of SSTs homo- and hetero-dimerization in the pituitary

inflammation Developmental exposures to common environmental pollutants result in long-term Reprogramming of hypothalamic-pituitary axis in mice GPCRs in Oncology and Immunology A disturbed metabolite-GPCR axis is associated with microbial

CRN04894, the company’s investigational candidate for the treatment of Cushing’s disease, congenital adrenal

neural cell populations to the regulation of metabolic processes in adipose tissue, liver, pancreas, adrenal

Structure-guided design of a peripherally restricted chemogenetic system Hye Jin Kang , Brian E Krumm , Adrien characterization Distribution and calcium signaling function of somatostatin receptor subtypes in rat pituitary

Taste Clinical, Pathophysiologic, Genetic, and Therapeutic Progress in Primary Bilateral Macronodular Adrenal

Findings At Endo 2024 For Atumelnant In Two Ongoing, Open-Label Studies For The Treatment Of Congenital Adrenal

From outside to inside and back again: the lysophosphatidic acid-CCN axis in signal transduction. Hauser on receiving 4.8 mill DKK from Carlsberg Foundation’s Semper Ardens: Accelerate programme.

This signaling axis was required for effective neutrophil-mediated skin immunity and microbiome homeostasis This study demonstrated the importance of epithelial-neutrophil signaling via the defensin-Mrgpra2 axis

discovery programs in key therapeutic areas Kallyope, pioneers in drug discovery involving the gut-brain axis biopharmaceutical company, and New York City-based Kallyope, pioneers in drug discovery involving the gut-brain axis

Exploiting Dependence of Castration-Resistant Prostate Cancer on the Arginine Vasopressin Signaling Axis These data indicate that the AVP/arginine vasopressin receptor signaling axis represents a promising

Immunology Clinical, pathophysiologic, genetic and therapeutic progress in Primary Bilateral Macronodular Adrenal

It is expressed in the paraventricular nucleus of the hypothalamus, where it interacts with various G

threat signals from different sensory modalities to multiple brain areas, such as the midbrain and hypothalamus

tissue specific responses during bacterial infections and emphasize the contribution of the C3a–C3aR axis

Protein-Coupled Receptors (GPCR) superfamily, and its ligand fractalkine constitute an important biochemical axis

These data reposition key roles of the L cell-gut IEL GLP-1R axis, revealing mechanisms linking GLP-1R

Together, these data reveal a shear-dependent signaling axis of PTK2, integrin αIIbβ3, and CIB1 in collagen

Small molecules biasedly modulating the TLR4 signaling axis not only provide probes to fine-tune receptor

should allow us to better appreciate the unique roles of ACKR3 in the CXCL12/CXCR4/ACKR3-signaling axis

CCR4Lc, CCR12a1, CCR12a2, and CCR12b) in largemouth bass (Micropterus salmoides) The pyruvate-GPR31 axis

GPCRs in Oncology and Immunology The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer