.- Jan Steyaert , scientific director of the VIB-VUB Center for Structural Biology , Vlaams Instituut Jan Steyaert will be presented with the Gabbay Award at Brandeis University on October 27 when he will

Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5391-3. doi: 10.1073/pnas.90.12.5391. Front Mol Neurosci. 2022 Jun 15;15:919773. doi: 10.3389/fnmol.2022.919773. Biochem Biophys Res Commun. 2023 Jan 15;640:64-72. doi: 10.1016/j.bbrc.2022.11.098.

activated, ERKs translocate to the nucleus, phosphorylating various transcription factors, including ETS, c-Jun

associate with the active parathyroid hormone 1 receptor (PTH1R) in different complex configurations ("hanging

The drugs also target relatively low-hanging fruit: like cytokines or tyrosine kinase receptors.

group box 1; HIF1A/HIF-1α: hypoxia inducible factor 1 subunit alpha; IHC: immunohistochemistry; JAK1: Janus

heterotrimeric G protein activity biosensors Marta Lopez-Balastegui , Antonella Di Pizio , Jiafei Mao , Jana

work on Highly biased agonism for GPCR ligands via nanobody tethering Elk Kossatz, Michel Bouvier, Jana

Jiang, L.I., et al., Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine

sulfated mCCR2 peptides can outcompete available chemokines, decreasing retinal degradation in mice (Jung

., Wang, B., Bouley, R., Potts, J. T., Gardella, T. J., & Vilardaga, J. P. (2009). Nature communications, 8(1), 443. https://doi.org/10.1038/s41467-017-00357-2 Jong, Y.

However, the receptors that these medicines target have been described as the ‘low-hanging’ fruit, and There are approximately 800 human GPCRs in the superfamily, controlling a broad range of physiological Orion’s receptor antagonist analogs have demonstrated powerful efficacies across a range of animal models