< GPCR News < GPCRs in Oncology and Immunology CB2 stimulation of adipose resident ILC2s orchestrates Group 2 innate lymphoid cells (ILC2s) play a critical role in maintaining adipose homeostasis via the endocannabinoid system, is expressed on both visceral adipose tissue (VAT)-derived murine and human ILC2s Our results show that CB2 stimulation of ILC2s protects against insulin-resistance onset, ameliorates therapeutic effects of CB2 are mediated through activation of the AKT, ERK1/2, and CREB pathways on ILC2s

IFNG-AS1 , IFNγ , IL , IL-13R , IL-13Rα1/2 , IL-1RαP , IL-31R , IL-31RA , IL-33R , IL-4Rα , IL-5Rα , ILC , ILC2 , IRF1 , IgE , Immunoglobulin E , Innate lymphoid cell , Interferon gamma-AS1 , Interferon regulatory

CXCR6 deficiency lowers TRM cell numbers in the lungs and depletes ILC3s in the lamina propria, impairing