Genetic variants in ITGA9, which encodes the α9 subunit of integrin α9β1, and SVEP1, a ligand for integrin

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The concurrent loss of ITGAE, CXCL16, and CXCR6 in chickens may have altered CD8 TRM cell abundance, Authors Buddhabhushan Girish Salve, Sandhya Sharma, Nagarjun Vijay Tags ITGAE , Chemokine receptors ,

Itaconate (ITA) rapidly accumulates to high levels in myeloid cells under infectious and sterile inflammatory Administration of ITA protects against inflammatory diseases and blockade of ITA production enhances In this article, we review ITA metabolism and its regulation, discuss its target proteins and mechanisms , and conjecture a rationale for developing ITA-based therapeutics to treat inflammatory diseases and