Scientific Data by Arne Hansen et a l has introduced a sensitive method for detecting GPCR mRNAs in human immune cells and platelets, revealing significant findings that enhance our understanding of GPCRs' roles in immune Additionally, the study identified unique expression patterns of GPCRs in different immune cell types immune responses and highlights the need for further functional studies to elucidate their specific Therefore this study significantly advances our understanding of GPCR expression in human immune cells

interfollicular regions of lymphoid tissues through binding the EBI2 (GPR183) to stimulate effective adaptive immunity

2022 "The endocannabinoid system plays a key role in the intersection of the nervous, endocrine, and immune It is well known that immune challenges, such as exposure to lipopolysaccharide, the main component of

schizophrenia-relevant brain circuits "Although the cannabinoid type-2 receptor (CB2) is highly expressed in the immune

August 2022 G protein-coupled receptor kinase type 2 and β-arrestin2: Key players in immune cell functions This review summarizes the roles of GRK2/β-arrestin2 in immune cell function and focuses on the pathological

resident leukocyte populations make it an ideal tissue to study interactions between the nervous and immune The cornea is the most densely innervated tissue of the body and possesses both immune and vascular privilege , in part due to its unique repertoire of resident immune cells. Corneal nerves produce various neuropeptides that have a wide range of functions on immune cells.

prevent skin dysbiosis and bacterial infection "Healthy skin maintains a diverse microbiome and a potent immune This signaling axis was required for effective neutrophil-mediated skin immunity and microbiome homeostasis combating S. aureus infections and the formation of neutrophil abscesses, a hallmark of antibacterial immunity release of IL-1β and CXCL2 which are vital for proper amplification and propagation of the antibacterial immune

exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation PAXIP1-AS1 is associated with immune infiltration and predicts poor prognosis in ovarian cancer A virally encoded GPCR drives glioblastoma

specializing in the discovery and development of new drugs targeting G Protein-Coupled Receptors (GPCRs) in immuno-oncology

atezolizumab and nab-paclitaxel has shown clinical activity in advanced TNBC with PD-L1-positive tumor-infiltrating immune cells. As tumor-associated macrophages (TAMs) serve as major contributors to the immuno-suppressive tumor microenvironment

GPR84 is a G protein-coupled receptor primarily expressed in myeloid cells that constitute the innate immune Infiltrating GPR84+ macrophages are significantly increased in the colonic mucosa of both the UC patients These results define a unique role of GPR84 in innate immune cells and intestinal inflammation, and suggest

provided a substantial body of evidence demonstrating that platelets also participate in host innate immunity interactions with neutrophils enhance neutrophil activation and are often crucial to induce a sufficient immune Here, virus infiltration may lead to a cytokine storm that potently activates neutrophils and leads to massive neutrophil infiltration into the lung and NET formation.

The immune system depends on chemokines to direct cell migration during immune surveillance and inflammation glycosaminoglycans (GAGs) to regulate the movement of leukocytes throughout the body, ensuring a functional immune

October 2022 "Perturbation of the endocannabinoid system can have profound effects on immune function types with a self-contained endocannabinoid system and are positioned at the interface between the immune

C3a, a product of C3 cleavage, which interacts with membrane-bound receptor C3aR to regulate innate immune has identified mechanistically distinct and cell type–specific roles for C3aR in regulating innate immune

S1P5 is predominantly expressed in nervous and immune systems, regulating the egress of natural killer cells from lymph nodes and playing a role in immune and neurodegenerative disorders, as well as carcinogenesis

comprising international leaders in GPCRs pharmacology, immunology, drug discovery and development for auto-immune

mesenchymal stem cells in multiple sclerosis patients Multiple sclerosis (MS) is a specific type of chronic immune-mediated disease in which the immune responses are almost run against the central nervous system (CNS). Chemokine/chemokine receptor axes play a pivotal role in the recruitment and oriented trafficking of immune

Another signaling pathway related to RGS4 involves the regulation of the immune response. RGS4 is expressed in various immune cells, including T cells and B cells, and has been shown to modulate immune cell activation and cytokine production. Wang, D., The essential role of G protein-coupled receptor (GPCR) signaling in regulating T cell immunity

phosphoinositide 3-kinase (PI3K) pathway, which plays fundamental roles in growth, metabolism, and immunity PI3Kγ is a critical component in multiple immune signaling processes and is dependent on activation by

with their receptors, are involved in various biologic processes and regulation of a wide range of immune

that regulate receptor phosphorylation and signaling termination, GRK2, which is highly expressed by immune

Redundancy can be exemplified by the tumor infiltration of Treg cells which can be driven directly by therapeutic modalities to modulate the stromal component, overcome chemotherapy resistance, and optimize immune

September 2022 "T cells are master regulators of the immune response tuning, among others, B cells, macrophages

are ancient large DNA viruses that have exploited gene capture as part of their strategy to escape immune

Expression of GPR84 is strongly up regulated in immune cells in a range of pro-inflammatory settings

receptor (GPCR), known as Mas-related G protein-coupled receptor-B2 (MRGPRB2), plays important roles in immune

Herein, we identified GPR108, a GPCR protein described in innate immune system, is a potential therapeutic