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< GPCR News < GPCRs in Oncology and Immunology PAXIP1-AS1 is associated with immune infiltration and infiltration of OC patients and its regulatory network are unclear. 379 OC tissues were collected from regression, Kaplan-Meier method, Cox regression analysis, Gene set enrichment analysis (GSEA), and immuno-infiltration The expression of PAXIP1-AS1 was associated with immune infiltration. low expression of PAXIP1-AS1 was Low expression of PAXIP1-AS1 was significantly associated with poor survival and immune infiltration

GPCRRG expression was correlated with immune infiltration rates. prognostic model elaborates on the roles of GPCRRGs in OV and provides a new tool for prognosis and immune Ruyue Li, Guangqi Li, Meng Wei, Bowei Li, Yongmei Li, Chunfang Ha Tags G protein-coupled receptor , Immune infiltration , Molecular marker , Ovarian cancer , Prognostic model , epithelial Source Contribute to

relationship between GPR37 gene expression and the clinicopathological factors, patient prognosis, tumor-infiltrating Besides, the "ssGSEA" algorithm was conducted to estimate immune cells infiltration abundance, with ' TIMER2.0 and ssGSEA showed that GPR37 expression was significantly associated with the infiltration of In addition, high GPR37 expression was positively correlated with increased infiltration of M2 macrophages infiltration , prognosis Source Contribute to the GPCR News Coming soon Become a Contributor Classified

The tumor immune dysfunction and exclusion (TIDE) algorithm was utilized to evaluate immune infiltration

< GPCR News < GPCRs in Oncology and Immunology Chemoattractant receptor signaling in humoral immunity Published date April 4, 2024 Abstract "Efficient induction of humoral immune responses depends on orchestrated chemoattractant receptors and plays an important role in the control of B cell migration during humoral immune summarize the current understanding of chemoattractant receptor signaling in the context of humoral immunity

emigration of metastatic, receptor-expressing cancer cells out of the tumor as well as immigration of tumor infiltrating immune cells that culminate in a tumor unique immune microenvironment. Facets of chemokine physiology across discrete cancer immune phenotypes are contrasted to existing chemokine-centered Authors Donovan Drouillard, Brian T Craig, Michael B Dwinell Tags Chemokine receptor; cell migration; immuno-oncology

Metabolite Concentrations in Portal Venous Blood as a Possible Mechanism for Microbiota Effects on the Immune Herein we propose a model for immune conditioning, whereby metabolites such as butyrate affect immune Deficiency of SCFA would lead to pro-inflammatory immune cell skewing through insufficient G-protein Such pro-inflammatory immune cells may travel to tissues such as the brain, the lung, the kidney etc Western lifestyle diseases, most of which are immune based, in tissues remote from the gut."

GPCRs in Oncology and Immunology Combinatorial depletions of G-protein coupled receptor kinases in immune Immune cells commonly express two to four members of the GRK family (GRK2, GRK3, GRK5, GRK6) simultaneously , but we have very limited knowledge about their interplay in primary immune cells. Together, our findings demonstrate the complexity of GRK functions in immune cells, which go beyond GPCR Furthermore, they highlight the need for studying GRK functions in primary immune cells to address their

< GPCR News < GPCRs in Oncology and Immunology GPCR signaling contributes to immune characteristics of Our multi-omics analysis of NKTCL revealed that EBV gene pattern correlated with immune-related oncogenic Single-cell transcriptome further delineated the tumor microenvironment as immune-inflamed, -deficient , and -desert phenotypes, in association with different setpoints of cancer-immunity cycle.

protein-coupled receptors: A target for microbial metabolites and a mechanistic link to microbiome-immune-brain inferred the most predominant GPCR-mediated microbial metabolite-human cell interactions regulating gut-immune-brain interactions with specific human cell receptors, particularly expressed on human intestinal epithelial cells, immune and metabolite cataloging with mechanistic studies for an improved understanding of gut microbiota-immune-brain Troyer , Suzi Hong Tags G protein-coupled receptors , Gut microbiota , Human-microbiota interactions , Immune

Adenosine 2a receptor (A2aR), a typical GPCR with a high affinity for adenosine, is widely expressed on immune cells, inhibiting anti-tumor immune response accordingly. closely related to their prognosis and positively correlated with tumor-associated macrophages (TAMs) infiltration Functionally, blocking A2aR significantly suppresses TAMs infiltration and attenuates tumor burden in

< GPCR News < GPCRs in Oncology and Immunology G protein coupled receptor transcripts in human immune

hormones, neurotransmitters, and odorants, some of which play critical roles in innate and adaptive immune Here, we demonstrate that GPR141, an orphan GPCR belonging to the class A receptor family, suppresses immune increased CD11b + Gr1+ neutrophils, CD11b + Gr1- monocytes, CD11c+ dendritic cells, and CD4+ T cell infiltration Lymphocytes enriched from Gpr141 -/- mice immunized with myelin oligodendrocyte glycoprotein 35-55 produced These findings suggest that GPR141 functions as a negative regulator of immune responses by controlling

< GPCR News < GPCRs in Oncology and Immunology Drosophila cytokine GBP2 exerts immune responses and regulates Here, we demonstrate that GBP2 replicates the GBP1-mediated cellular immune response from Drosophila Our finding revealed that Drosophila GBP1 and GBP2 control immune responses as well as their own expression

Contest Committee Sponsors GPCR Retreat Program < Back to schedule Targeting adenosine signaling for immuno-oncology signaling through A2A and A2B G protein-coupled receptors is increasingly recognized as an important immune checkpoint in the generation of anti-tumor immunity. identified the adenosine-producing enzyme CD73 as a new cancer target, and for his translational work in immuno-oncology immunotherapies, and member of the SAB of Domain Therapeutics, a biopharmaceutical company focused on GPCR in immuno-oncology

< GPCR News < GPCRs in Oncology and Immunology Identification of S1PR4 as an immune modulator for favorable

and Immunology Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune , Maria Gonzalez-Nunez , Ana Chopo-Pizarro , Jesmond Dalli Tags Acute inflammation , GPCR , Innate immunity

directing GPCR and lipid second messenger signaling Published date November 11, 2023 Abstract "Tissue infiltration GPCRs) are essential for sensing chemokine gradients and directing the movement of leukocytes during immune -bisphosphate (PIP2) and phosphatidylinositol 3,4,5-triphosphate (PIP3) to spatiotemporally control immune

protein-coupled receptors (GPCRs) are essential contributors to tumor growth and metastasis due to their roles in immune Additionally, we focus on the roles of GPCRs in regulating immune checkpoint proteins involved in immune Authors Guang-Hong Qiu, Bin Yu, Mei Ma Tags GPCRs , cancer immune checkpoints , cancer immunotherapy , immune cells , tumor microenvironment .

GPCR News < GPCRs in Oncology and Immunology CB2 stimulation of adipose resident ILC2s orchestrates immune

promotes T cell dysfunction and cancer immunotherapy failure Published date June 12, 2023 Abstract "Immune G-protein-coupled receptors (GPCRs) are the most intensively studied drug targets but are underexplored in immuno-oncology These data indicate that Gαs-GPCRs are druggable immune checkpoints that might be targeted to enhance

from the diet and the microbiota, serve as crucial links between the diet, gut microbiota, metabolism, immunity pathways, and gene expression in cells within the tumor microenvironment, particularly in tumor and immune Duan, Shudi Luo, Fangxin Zhou, Qingang Wu, Zhimin Lu Tags acetate , butyrate , cancer , cell death , immune

Despite their crucial role in regulating antitumor immunity and tumorigenesis, therapeutic applications the review highlights five GPCRs able to orchestrate tumor immunobiology at three main levels: tumor immunity Donato Inverso, Carlotta Tacconi, Serena Ranucci, Marco De Giovanni Tags Angiogenesis , Cancer , GPCRs , Immunity

SCI-IDS predominantly occurs following injury above the T5 levels and eventually leads to systemic immune and the HPA axis was explored by histology and multitissue transcriptomics, and the neuroendocrine-immune Results: The spleen and thymus gland, which are secondary immune organs, were significantly atrophied rt1-da, rt1-ba, cd74, cxcr3, vcam1, ccl5, bin1, and IL8) were significantly enriched in MHC-mediated immune this study assessed the differential regulation of the gene network associated with neuroendocrine immunity

nucleotides to their respective di and mono-phosphate nucleoside forms, contributing significantly to immune protein-coupled receptors (GPCR) (P2Y) interact with ATP and other nucleotides, influencing diverse immune diminishing ATP-dependent activation and generating adenosine (ADO), potentially hindering antitumor immunity to devise strategies combating e-ATP/ADO-induced immunosuppression, ultimately enhancing anti-tumor immunity

Novoprotein developed a NovoiSMART technology, utilizing mRNA-based immunization, which can overcome These studies show that mRNA immunization yields higher antibody titers and greater epitope diversity

dendritic cells (DCs) which can release interleukin 23 (IL-23) to interlink the innate and adaptive immunity knockout (K14-cKO) mice models to explore the function of GPR97 which influences keratinocytes and skin immunity Role of GPR97 is indispensable and this adhesion receptor may affect immune cell enrichment and function

treatment of obesity and Type 2 Diabetes (T2D) by exploring metabolically important signaling pathways in immune knock-out and transgenic mouse models, along with different cell culture systems, to understand the role of immune