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February 2022 "Switzerland Today, InterAx Biotech is pleased to announce that Carola Weiss has joined Carola Weiss is a Senior Executive with more than 20 years of international experience in the biopharmaceutical

February 2022 "InterAx Biotech AG and Boehringer Ingelheim take first steps towards collaborating to unlock orphan targets leveraging InterAx AI driven discovery platform. first-in-class small molecule agonists for a challenging orphan GPCR for a highly relevant therapeutic need. 💊 InterAx Biotech AG discovery platform was already successfully applied in projects with biopharmaceutical companies #ai #biotech #systemsbiology #drugdiscovery #gpcr #deeptech #orphandrugs #pharma #partnerships #AI4drugdiscovery

Joanne Waldstreicher to its Board of Directors GPCR Therapeutics launches multiple myeloma trial Salipro Biotech Japan, organized by LINK-J Jounce takes the cash under amended deal with Gilead on anti-CCR8 antibody InterAx Biotech Announces the Appointment of Seasoned Pharmaceutical Executive, Dr. SLAS2023 International Conference and Exhibition (February 25 - March 1, 2023). 2nd ERNEST Training School

Industry News InterAx Biotech to Apply its Leading AI and Cell Signalling Technology to Support Target Validation for a Sosei Heptares GPCR Discovery Program Salipro Biotech and DyNAbind Announce Milestone Addex Announces ADX71149 Phase 2 Epilepsy Clinical Study’s Independent Interim Review Committee Recommends

Operational Highlights and Consolidated Results for the Third Quarter and First Nine Months of 2023 InterAx Biotech Announces Being the Recipient of a Highly Competitive European Grant to Fund Drug Development Scientific Meeting NEW January 16 - 19, 2024 | 23rd Annual PEP Talk February 3 - 7, 2024 | SLAS2024 International

neutrophils by promoting an alternative-like polarization during bacterial infection Industry News InterAx Biotech's AI platform unlocks new drug designs for diabetes, obesity, and cancer Crinetics Pharmaceuticals

July 2022 "G.CLIPS biotech is 2 years old today🎂. Looking forward for more 🎊 #team #grateful #biotech #work #birthdaycelebration" Read more at the source

October 2022 Intermolecular Interactions in G Protein-Coupled Receptor Allosteric Sites at the Membrane Interface from Molecular Dynamics Simulations and Quantum Chemical Calculations "Allosteric modulators binding location that raises many questions about the ligand interactions and stability, the binding In this work, we analyze interactions in the allosteric sites of the PAR2, C5aR1, and GCGR receptors The availability of polar atoms for interactions in such cavities can be assessed by water molecules

the architect behind nearly all of Exscientia's partnerships and collaborations across pharma and #biotech⁠

#biotech #lifesciences #appointment #GPCR #Oncology" Read more at the source #DrGPCR #GPCR #IndustryNews

Upon agonist activation, the DOR-APEX2 complex is internalized and trafficked to the lysosome.

Classically, GPCR internalization has been considered to lead to receptor desensitization. However, many studies over the past decade have reported that internalized membrane receptors can trigger The "internalized activation" provides a completely new understanding for the receptor internalization Here, this review summarizes different PTMs in GPCR internalization and analyzes their significance in GPCR internalization dynamics, internalization routes, postinternalization fates, and related diseases

Actions Adher’n Rise and ERNEST plus DFG-funded CRC1423 and RU2372) have joined forces to organize an international We aim to connect renowned international experts of the field with early career ‘rising stars’.

GPCRs are present in a range of conformations, and the binding of a ligand, as well as interactions with Depending on the specific functional outcome measured (e.g. activation, interaction with accessory proteins , dimerization, phosphorylation, internalization, or desensitization), the same drug acting on the same

"We are moving ahead with SLAS2022 as an in-person event with a hybrid component. We are closely monitoring any regulation changes from both Boston and Massachusetts with regard to in-person events. If there are any changes made that will impact our ability to hold the event in-person, we will notify the SLAS community as soon as possible. Please refer to our Safe Meeting guidelines for information about how you can participate in the event in-person. Don't miss the chance to present your innovative research at this year's conference. Poster abstracts for in-person and virtual presentations will be accepted through Monday, January 24." Register here

September 2022 Interacting binding insights and conformational consequences of the differential activity Here, using computational methods, we investigate the interacting determinants of CBD in two closely From our detailed characterization, we found particular interacting loci in the binding sites of the

#IPO #biotech #innovation #traitements #addiction #cannabis #Trisomie21 #Downsyndrome" Read more at the

September 2022 Ginsenoside Rg5 allosterically interacts with P2RY12 and ameliorates deep venous thrombosis

September 2022 GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization Our results showed that the inhibition of cellular respiration hindered the internalization of F-Hst1 Overall, phagocytosis, CME, GPCR, ERK signaling, and S2R/TMEM97 are involved in the internalization of The inhibition of either internalization or mitochondria-targeting of Hst1 could significantly compromise

We are able to identify the interaction of membrane cholesterols with definite sites and domains within We show that cholesterol interactions with the transmembrane domain TMD, unlike those with the cysteine-rich Notably, a few persistent interactions of cholesterol with lower TM cholesterol-binding domains are governed We have also reported the interaction of phosphatidylinositol 4-phosphate with the intracellular region The movement of these TM helices could possibly be a consequence of interactions involving the extracellular

August 2022 A new Kunitz-type snake toxin family associated with an original mode of interaction with and non-active V2R Kunitz peptides highlighted five positions, among which four are involved in V2R interaction We finally determined that eight positions, part of these two loops, interact with the V2R.

GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between Health

G protein-coupled receptor interactions and modification of signalling involving the ghrelin receptor 1a (GHSR1a) is intriguing because of its potential as a therapeutic target and its diverse molecular interactions In all cases, the receptor interaction changes downstream signalling and the responses to receptor agonists

resonance (NMR) spectroscopy allows the determination of atomic-level information on intermolecular interactions In particular, we focus on the application of on-cell NMR spectroscopy to characterize ligand interactions

September 2022 CCL25/CCR9 interaction promotes the malignant behavior of salivary adenoid cystic carcinoma signaling pathway "Background CC chemokine receptor 9 (CCR9), an organ-specific chemokine receptor, interacts Western blot and RT–qPCR assays were carried out to measure the downstream factors of the interaction

Multiple 14-3-3 isoforms exist, and a GPCR can differentially interact with different 14-3-3 isoforms

This is a highly prestigious international award – exemplified by the fact that other winners this year are the co-founders of BioNTech for their invention of the (Pfizer) Covid vaccine."

We uncovered a novel neuroprotective mechanism involving interaction between neurotrophic factor-α1 ( Co-immunoprecipitation and pull-down assays confirmed interaction between NFα1/CPE and 5-HTR1E and 125I Molecular dynamics studies revealed that NF-α1/CPE interacts with 5-HTR1E via 3 salt bridges, stabilized Thus, NF-α1/CPE uniquely interacts with serotonin receptor 5-HTR1E to activate the β-arrestin/ERK/CREB