nodes in various biological processes, and both of them regulate cell proliferation and promote cell invasion

and apoptosis were evaluated using Cell Counting Kit-8 and colon formation, and cell migration and invasion

It effectively attenuates PAR2&4-Akt/PKB associations; PAR4 instigated Matrigel invasion and migration

GPCRs in Oncology and Immunology Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion Invasion assays using a 3D spheroid model revealed P2Y 2 to be critical in facilitating invasion driven genetic modification and pharmacological strategies we demonstrate mechanistically that this ATP-driven invasion receptor-integrin interactions were required for effective downstream signalling, leading to cancer cell invasion This work elucidates a novel GPCR-integrin interaction in cancer invasion, highlighting its potential

< GPCR News < GPCRs in Oncology and Immunology NPFF stimulates human ovarian cancer cell invasion by Treatment of SKOV3 cells with NPFF did not affect cell viability and proliferation but stimulated cell invasion addition, blocking the activation of ERK1/2 signaling abolished the NPFF-induced MMP-9 expression and cell invasion This study provides evidence that NPFF stimulates EOC cell invasion by upregulating MMP-9 expression Authors Ze Wu , Qiongqiong Jia , Boqun Liu , Lanlan Fang , Peter C K Leung , Jung-Chien Cheng Tags Invasion

measured the effects of NPY1R and NPY5R antagonists in normoxia and hypoxia on migration, proliferation, invasion hypoxia compared to normoxia more greatly reduced MAPK signaling, cell proliferation, cell migration and invasion , and spheroid growth and invasion. The estrogen receptor positive MCF7 cells were significantly less invasive in 3D spheres when NPY5R was