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GPCRs in Oncology and Immunology Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion Invasion assays using a 3D spheroid model revealed P2Y 2 to be critical in facilitating invasion driven genetic modification and pharmacological strategies we demonstrate mechanistically that this ATP-driven invasion receptor-integrin interactions were required for effective downstream signalling, leading to cancer cell invasion This work elucidates a novel GPCR-integrin interaction in cancer invasion, highlighting its potential

< GPCR News < GPCRs in Oncology and Immunology NPFF stimulates human ovarian cancer cell invasion by Treatment of SKOV3 cells with NPFF did not affect cell viability and proliferation but stimulated cell invasion addition, blocking the activation of ERK1/2 signaling abolished the NPFF-induced MMP-9 expression and cell invasion This study provides evidence that NPFF stimulates EOC cell invasion by upregulating MMP-9 expression Authors Ze Wu , Qiongqiong Jia , Boqun Liu , Lanlan Fang , Peter C K Leung , Jung-Chien Cheng Tags Invasion

measured the effects of NPY1R and NPY5R antagonists in normoxia and hypoxia on migration, proliferation, invasion hypoxia compared to normoxia more greatly reduced MAPK signaling, cell proliferation, cell migration and invasion , and spheroid growth and invasion. The estrogen receptor positive MCF7 cells were significantly less invasive in 3D spheres when NPY5R was

GPCR News < GPCRs in Oncology and Immunology Lactate receptor GPR81 drives breast cancer growth and invasiveness GPR81 KD increased spheroid necrosis, reduced invasion and in vivo tumor growth, and altered expression ), was strikingly downregulated upon GPR81 KD, and DLL4 KD elicited spheroid necrosis and inhibited invasion

Furthermore, we examined the effects of GPR37 on tumor cell apoptosis and invasion. predicts an unfavorable prognosis. (2) It was demonstrated that GPR37 positively regulates NSCLC cell invasion Conversely, we observed that GPR37 knockdown suppresses NSCLC cell invasion, migration, and proliferation

Flowcytometry and Transwell assays were performed to observe the changes in cell apoptosis, metastasis and invasion /GPR39/PKC, which accordingly resulted in suppressed cell apoptosis and promoted cell migration and invasion

Ductal carcinomas are increasingly diagnosed but identifying which will progress to invasive disease Planar cell polarity (PCP) proteins contribute to tumour growth and invasion. luminal-type breast cancer cell lines representative of breast carcinomas with lower versus higher invasive To test the specific hypothesis that biased expression of CELSR1 isoforms will predict invasive potential or invasive features, the latter including heterogeneous tumours with mixed pathology.

The precise mechanisms by which ACs contribute to cancer cell proliferation and invasion are not well

and polarizing factors through activating PI3K/AKT/NF-κB pathway, thereby promoting the migration and invasion

, we show that GPR143 promotes metastasis by secreting exosomes and increasing cancer cell motility/invasion

their contribution to the progression of cancers, such as prostate and ovarian cancer, facilitating the invasive

Results show that the elevated expression of UCA1 enhances cell proliferation, invasive migration, and

Invasive procedures alone are not effective at completely removing such tumors.

associated with G protein-coupled receptor (GPCR) pathways which have been described to support growth, invasiveness

In contrast, during metastasis, where invasion is the primary task, the isoform switches back to the

expression in OC was associated with age (P = 0.045), histological grade (P = 0.011), and lymphatic invasion

targets an enzyme involved in mRNA cleaving, which has been found to stop cancer cells from growing and invading