August 2022 "Despite the importance of members of the GPCR superfamily as targets of a broad range of Expression of GPR84 is strongly up regulated in immune cells in a range of pro-inflammatory settings

In addition to the RGS domain, RGS proteins also contain a range of other structural motifs that are : Recent studies have revealed that the interaction between RGS proteins and GPCRs is mediated by a range of RGS protein dysregulation in disease: The Dysregulation of RGS proteins has been implicated in a range The dysregulation of these proteins has been implicated in a range of diseases, and understanding the Wang, Q., L.Y. Liu-Chen, and J.R.

well as target validation strategies for the discovery and development of novel therapeutic agents ranging

this review, we have compared expression of GPCR mRNAs in human islets obtained from normal weight range donors, and those with a weight range classified as obese.

clinical-stage global biopharmaceutical company developing novel oral therapeutics to treat a wide range

develop a deep pipeline of novel, targeted, nonpeptide radiopharmaceuticals for the treatment of a broad range develop a deep pipeline of novel, targeted, nonpeptide radiopharmaceuticals for the treatment of a broad range

cytokines along with their receptors, are involved in various biologic processes and regulation of a wide range

recent years as researchers have discovered the vast potential for GPCR-targeting drugs in treating a range

"G protein-coupled receptors (GPCRs) are of considerable interest due to their importance in a wide range

GRK2/β-arrestin2 play multiple roles in the pathological mechanisms of a wide range of diseases including

candidate into clinical trials " HTL0039732 is a novel EP4 antagonist with potential to treat a wide range

detection, receptor activation initiates conformational changes, exposing an intracellular cavity (Kang Despite multifocal signaling, recent studies indicate that signaling occurs within a 100 nm range from high-resolution protein structures, illuminating side chain orientations and overall conformational states (Kang

August 2022 "As important drug targets, G protein-coupled receptors (GPCRs) play pivotal roles in a wide range

G protein-coupled receptors (GPCRs) are crucial receptors that regulate a wide range of physiological

ligands are versatile molecular tools to study G protein-coupled receptors (GPCRs) and can be used for a range

Corneal nerves produce various neuropeptides that have a wide range of functions on immune cells.

associate with the active parathyroid hormone 1 receptor (PTH1R) in different complex configurations ("hanging

GPCRs respond to a wide variety of signals that range in size from photons to proteins (Foord et al.,

Hence, it has wide applicability across a spectrum of neuroscience research, ranging from the study of

The drugs also target relatively low-hanging fruit: like cytokines or tyrosine kinase receptors.

2022 "G protein-coupled receptors (GPCRs) are signaling hubs in cell membranes that regulate a wide range

Modes "G protein-coupled receptors (GPCRs) are signaling hubs in cell membranes that regulate a wide range

Modern drug development approaches include a range of techniques leveraging structural biology, immunology

fluorescent GPCR ligands "G-protein coupled receptors (GPCRs) have been largely targeted in a wide range

fragment- and seven lead-like compounds were confirmed to bind to the allosteric site with affinities ranging

diseases, (d) showed spontaneously fluctuating Ca levels from approximately normal to near fatally high ranges

fragment- and seven lead-like compounds were confirmed to bind to the allosteric site with affinities ranging

We show that besides classical hydrogen bonds, weak polar interactions such as O-HC, O-Br, and long-range