then regulate trigger receptor internalization via interaction with the adaptor protein 2 (AP2) and clathrin receptor on the plasma membrane directly and remains attached to the same receptor until they reach clathrin-coated event extends the duration of β-arrestin at the plasma membrane, enabling it to independently reach clathrin-coated the plasma membrane leads to their recruitment and accumulation in CCPs via interaction with AP2 and clathrin

Molecular signature of CCR2 scavenging - no G proteins, no GRKs, no arrestins, and no clathrin Chemokine Then β-Arrestin recruitment takes place allowing receptor internalization through clathrin-mediated pits Although some GPCRs constitutively internalize through clathrin-coated pits independently of phosphorylation Parent, et al. 2001), inhibition of clathrin-mediated endocytosis (CME) did not affect the ability of

We show that epitope-tagged GCGRs undergo clathrin- and dynamin-dependent endocytosis in HEK293 and Huh

Kathryn E Livingston About Dr. Kathryn E Livingston Dr. Kathryn E Livingston is currently a Product Manager at Gator Bio , a biotechnology company providing Kathryn obtained her BS in Chemistry from Carnegie Mellon University and went on to receive a Ph.D. in Following this, Kathryn did a post-doctoral fellowship at UCSF in the laboratory of Dr. Kathryn E Livingston on the web LinkedIn ResearchGate Pubmed Google Scholar Dr.

Authors Michael Trogdon, Kodye Abbott, Nadia Arang, Kathryn Lande, Navneet Kaur, Melinda Tong, Mathieu

Authors Pravita Balijepalli , Kathryn E Meier Source Contribute to the GPCR News Coming soon Become a