then regulate trigger receptor internalization via interaction with the adaptor protein 2 (AP2) and clathrin receptor on the plasma membrane directly and remains attached to the same receptor until they reach clathrin-coated event extends the duration of β-arrestin at the plasma membrane, enabling it to independently reach clathrin-coated the plasma membrane leads to their recruitment and accumulation in CCPs via interaction with AP2 and clathrin

Molecular signature of CCR2 scavenging - no G proteins, no GRKs, no arrestins, and no clathrin Chemokine Then β-Arrestin recruitment takes place allowing receptor internalization through clathrin-mediated pits Although some GPCRs constitutively internalize through clathrin-coated pits independently of phosphorylation Parent, et al. 2001), inhibition of clathrin-mediated endocytosis (CME) did not affect the ability of

We show that epitope-tagged GCGRs undergo clathrin- and dynamin-dependent endocytosis in HEK293 and Huh

The inhibitors of GPCR, ERK1/2, phagocytosis, and clathrin-mediated endocytosis (CME) as well as siRNA

β-arrestin pathway under Gi/o activation-MOR, being crucial the formation of β-arrestin/ β2-adaptin and clathrin The molecular associations in clathrin-coated pit regulate β-arrestin-mediated MAPK signaling downstream

This study revealed that CCR2 scavenging is independent of G proteins, GRKs, arrestins, as well as clathrin

The molecular associations in clathrin-coated pit regulate β-arrestin-mediated MAPK signaling downstream

internalization. β-Arrestins facilitate this process by interacting with adapter protein 2 (AP-2) and clathrin This includes proteins like AP-2 and clathrin, vital for internalization, as well as MAPK cascade kinases

This week's highlight includes congrats to: Christina Katharina Kuhn, Drs.

Katharina Grotsch, Bryan L Roth, Valery V Fokin  et al. for their research on Virtual Screening of a