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Author Kenneth T Bogen Tags Asbestos , Cytotoxicity , Inflammation , Lung cancer , Mesothelioma , Mutation

Kenneth A. Jacobson About Dr. Kenneth A. Jacobson Kenneth A. Kenneth A. Jacobson on the web NIDDK Web of Science Google Scholar LinkedIn Twitter Dr.

RNAi library screening reveals Gβ1, Casein Kinase 2 and ICAP-1 as novel regulators of LFA-1-mediated T and migration Published date November 28, 2024 Abstract "The αLβ2 integrin LFA-1 plays a key role in T-cell cell line model of LFA-1-stimulated T-cell migration. and provides potential novel targets for modulation of the T-cell immune response." Authors Antje Haap-Hoff, Michael Freeley, Eugene Dempsey, Dara Dunican, Emily Bennett, Denise Triglia

< GPCR News < GPCRs in Oncology and Immunology GPR15 expressed in T lymphocytes from RA patients is involved of synovial fluid and peripheral blood were analyzed for CD45+CD3+CD4+GPR15+ and CD45+CD3+CD8+GPR15+ T Statistical analysis included Kruskal-Wallis test, T-test, or Mann-Whitney U test, according to data Also, the frequency CD4+/CD8+ GPR15+ T lymphocytes are higher in synovial fluid of established RA patients Tags C10ORF99; GPR15; GPR15L; T lymphocytes; chemotaxis; rheumatoid arthritis; synovium.

< GPCR News < GPCRs in Oncology and Immunology The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction Here, we cross-integrated large singe-cell RNA-sequencing datasets from CD8+ T cells covering 19 distinct cancer types and identified an enrichment of Gαs-coupled GPCRs on exhausted CD8+ T cells. These include EP2, EP4, A2AR, β1AR and β2AR, all of which promote T cell dysfunction. Gαs-DREADD to activate CD8-restricted Gαs signaling and show that a Gαs-PKA signaling axis promotes CD8+ T

receptors induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways in primary T to activate the phosphatidylinositol pathway and induce interleukin-2 production in Jurkat leukemic T that activating the pAKT pathway is critical for IL-2 production in T cells." Authors Trang T T Nguyen , Wen Lu , Wandi S Zhu , K Mark Ansel , Hong-Erh Liang , Arthur Weiss . Tags GPCR; T cells; muscarinic receptor; signaling.

Immunology Bispecific antibodies targeting BCMA or GPRC5D are highly effective in relapsed myeloma after CAR T-cell date December 5, 2024 Abstract "Despite the astonishing outcomes after chimeric antigen receptor (CAR) T-cell There are only limited data available on salvage therapies following relapse after BCMA-directed CAR T-cell Here, we analyzed outcomes of post-CAR T-cell therapy relapse and impact of different salvage strategies The median time to relapse after CAR T-cell therapy was 5 months, 53% had the extramedullary disease

< GPCR News < GPCRs in Oncology and Immunology A GPCR checkpoint drives CD8+ T cell dysfunction and immunotherapy

< GPCR News < GPCRs in Oncology and Immunology The EBI2 receptor is coexpressed with CCR5 in CD4+ T cells Methods: We identified GPCRs expressed in primary CD4+CCR5+ T cells by multi-RT-qPCR. Results: We showed that EBI2 is naturally expressed in primary CD4+CCR5+ T cells, and that CCR5 and EBI2 in blood and lymphoid tissues, the constant EBI2 activation might increase HIV replication in CD4+ T

The combination of brentuximab vedotin and chidamide synergistically suppresses the proliferation of T-cell through the enhancement of apoptosis Published date November 3, 2023 Abstract " Purpose: Peripheral T-cell HH cells, originating from an aggressive cutaneous T-cell lymphoma, were used as an experimental model Conclusion: The use of chidamide in conjunction with BV may positively affect and enhance T-cellular Junpei Soeda , Yoshihide Kakimoto Tags Apoptosis , Bcl-2 , Brentuximab vedotin , CDC45 , Chidamide , T-cell

Immunology Respiratory infections predominate after day 100 following B-cell maturation antigen-directed CAR T-cell important complication after B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T-cell We evaluated infections in 99 adults who received a first BCMA-directed CAR T-cell therapy (commercial and investigational autologous BCMA CAR T-cell products at the recommended phase 2 dose) for relapsed Respiratory infections predominate after BCMA CAR T-cell therapy, particularly after day 100.

< GPCR News < GPCRs in Oncology and Immunology TIPE proteins control directed migration of human T cells two human TIPE family members, TNFAIP8 and TIPE2 were essential for directed migration of human CD4+ T T Cells deficient in both of these proteins completely lost their directionality. Collectively, our work describes a new mechanistic paradigm for how human T cells integrate GPCR and

therapy (CAR-T), bispecific-antibodies (BsAb) and antibody-drug-conjugates (ADC). Amongst 256 patients, 92 received CAR-T, 55 BsAb and 109 ADC. The incidence of severe infections was higher with BsAb (40%) than CAR-T (26%) or ADC (8%), including Comparing T-cell redirecting therapies, the incidence rate of severe infections was significantly lower with CAR-T compared to BsAb at 1-year (incidence-rate-ratio [IRR] = 0.43, 95%CI 0.25-0.76, P = 0.004

Thura , Abhishek Gupta , Sheng Hui Tan , Kelvin Kam Yew Kuan , Koon Hwee Ang , Khurshid Merchant , Kenneth

Methods: We disrupted the PR gene (PGR) in ERα-positive/PR-positive T-47D cells using the CRISPR/Cas9 in cell pools we termed PR-low as P4 mediated effects were inhibited or blocked compared to control T- We analyzed the gene expression profiles of PR-low and control T-47D cells in the absence of hormone The overall gene expression pattern was very similar between untreated PR-low and untreated control T- More than 6000 genes were DE in control T-47D cells upon stimulation with P4 or P4 plus E2.

to the positive regulation of macrophage derived foam cell differentiation, negative regulation of T TIMER2.0 and ssGSEA showed that GPR37 expression was significantly associated with the infiltration of T cells, CD8 T cell, eosinophils, macrophages, neutrophils, NK CD56dim cells, NK cells, plasmacytoid DCs (pDCs), T helper cells and T effector memory (Tem) cells.

of 10 kDa (IP-10/CXCL10) is a dual-function CXC chemokine that coordinates chemotaxis of activated T , second messenger signaling downstream of CXCR3, and flow cytometry of CHO cells and primary human T Furthermore, CXCL10(1-73) incited significantly less primary human T lymphocyte chemotaxis in vitro and peritoneal ingress of CXCR3+ T lymphocytes in mice. C-terminal residues Lys74-Pro77 of CXCL10 are important for GAG binding, signaling through CXCR3A, T

of single, combinatorial and complete GRK knockouts in four primary immune cell types (neutrophils, T Combined depletion of GRK2 and GRK6 in T cells and B cells shows distinct functional outcomes for (a) Katharina M Glaser, Teresa K Tarrant, Tim Lämmermann Tags B cells; G-protein coupled receptors; GRK; T

rendered it an attractive target for therapeutic interventions, including monoclonal antibodies, CAR-T cells, and T-cell engagers.

2023 Abstract "Dendritic cells (DCs) and monocytes capture, transport, and present antigen to cognate T Authors Kavita Rawat , Anita Tewari , Xin Li , Arlind B Mara , William T King , Sophie L Gibbings , Chinaza

Here we reported the first comprehensive proteogenomic characterization of natural killer/T-cell lymphoma Therapeutic targeting CCR1 showed promising efficacy with EBV eradication, T-cell activation, and lymphoma

Abstract "The CXCL16-CXCR6 axis is crucial for regulating the persistence of CD8 tissue-resident memory T Chemokine receptors , DRY/DRF/DRL motif , GC-rich gene , GPCR , Mucosal immunology , Tissue-resident memory T

accompanied by decreased creatinine clearance and urea excretion and a decreased presence of regulatory T increased activation of the immune system and a higher production of pro-inflammatory cytokines by T

showed increased CD11b + Gr1+ neutrophils, CD11b + Gr1- monocytes, CD11c+ dendritic cells, and CD4+ T Gpr141 -/- mice increased cytokine production of myelin oligodendrocyte glycoprotein 35-55-specific T

roles of AGPCRs in the periphery ADGRG1/GPR56 regulates survival of terminally differentiated CD8+ T health and disease Douglas Tilley ADGRG1/GPR56 regulates survival of terminally differentiated CD8+ T

McCleskey, sensory neuron properties); Pain Management Research Institute (more opioids, cannabinoids and T-type

Randall T.

Many ADGRs are autoproteo-lytically cleaved at the GPCR proteolysis site (GPS), an HXS/T motif within unique structural features that are important for autoproteolytic cleavage, beyond the canonical HXS/T protein regions, whose dynamics mediate solvent-accessibility of the catalytically active GPS triad HL|S/T,