October 2022 Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent We generated mutant mouse lines lacking the entire Defensin (Def) gene cluster in keratinocytes or Mrgpra2a

homeostasis (Gelis L. et. al 2016) and the sandalore-activated receptor OR2AT4 shown to promote human keratinocyte

helper 17 (Th17) cell differentiation leading to elevated production of interleukin 17 (IL-17) for keratinocytes keratin 14-conditional knockout (K14-cKO) mice models to explore the function of GPR97 which influences keratinocytes In addition, hyperproliferative keratinocytes as well as accumulation of DCs and Th17 cells were detected indispensable and this adhesion receptor may affect immune cell enrichment and function in skin and alter keratinocytes , Li Zhang, Ying Zhou, Jie Yao, Yixin Duan, Cong He, Shuai Jiang, Wenzheng Jiang Tags DCs , GPR97 , Keratinocytes