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functional specificity at C-X-C chemokine receptor 5 (CXCR5) Panjamaporn Sangwung , Alejandra Tomas , Kyle Sloop , et al. for their outstanding study on Class B1 GPCRs: insights into multireceptor pharmacology

Greetings, GPCR Colleague! Prepare to be amazed! Shocking GPCR revelations await you. Explore the newest breakthroughs and thrilling research findings in this week's update! This Week’s Highlights: Celebrating Excellence:   Patrick Sexton  and Arthur Christopoulos  Named Among Top 1% of Scientists in Pharmacology and Toxicology for 2024 ! High-affinity agonists reveal recognition motifs for the MRGPRD GPCR Chunyu Wang ,  Yongfeng Liu ,  Marion Lanier ,   Brian K Shoichet ,  Esther Martinborough ,  Jonathan F Fay ,  Can Cao ,   Bryan L Roth , et al. Pancreatic ductal adenocarcinoma, β-blockers and antihistamines: A clinical trial is needed Jillian G Baker ,  Erica K Sloan ,   Kevin Pfleger ,  Peter J McCormick , Cristina Salmerón ,   Paul A Insel PGxDB: an interactive web-platform for pharmacogenomics research Trinh Trung Duong Nguyen ,  Ziaurrehman Tanoli ,  Saad Hassan , Umut Onur Özcan ,   Jimmy Caroli ,   Albert J Kooistra ,   David E Gloriam ,   Alexander S Hauser GPCRdb in 2025: adding odorant receptors, data mapper, structure similarity search and models of physiological ligand complexes Luis P Taracena Herrera , Søren N Andreassen ,   Jimmy Caroli ,   Albert J Kooistra , Gáspár Pándy-Szekeres ,   David E Gloriam , et al. A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR Lior Peri ,  Donna Matzov ,  Dominic R Huxley ,   Peter Gmeiner ,  Peter J McCormick ,  Dorothee Weikert ,  Masha Y Niv ,  Moran Shalev-Benami , et al. Dr. GPCR Kicked Off as a Podcast... Now, we're making our dream a reality by bringing together everyone in the field to grow and thrive as a GPCR Community with: One-of-a-kind educational experiences and resources.  Sharing groundbreaking research and industry updates. A single platform to connect from anywhere in the world  And if you go for a Premium Membership , you'll not only back our mission but also snag fantastic perks like: Dr. GPCR University 🎥 Recorded GPCR Courses and Symposia / Summit 💲 Special Pricing on GPCR courses GPCR Forum Initiate a captivating conversation or seek assistance with your research. GPCR Events You can begin organizing and marking a few dates in 2025 . GPCR Jobs Seeking employment or hiring? This is the spot! Schedule a session with our Chief Match Maker. Direct line to the Dr. GPCR community members Connect with fellow GPCR enthusiasts :) So much more to come! 🕵️‍♂️We'll soon be unveiling our University CheatSheet! 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Classified GPCR News  Let’s dive into the   Classified GPCR News from November 18th to 24th, 2024 Industry News Amgen Announces Senior Executive Research Appointment St. Jude Children's Research Hospital Welcomes Dr. Georgios Skiniotis as Director of the New Center of Excellence for Structural Cell Biology Monash Scholars Ranked in Global Top 1% Septerna Poised For Biopharma Breakthrough: Analysts Cite GPCR Innovation And 2025 Milestones Recursion and Exscientia have merged to enhance drug discovery GPCR Classes Pathios Therapeutics Announces Dosing of First Patient in Phase 1/2 Clinical Study of GPR65 Inhibitor PTT-4256 in Patients with Advanced Solid Cancers GPCR drugmaker Septerna amasses $288M in IPO Surrounded by AI bio giants, tiny startup Nabla Bio makes de novo antibodies look more like drugs  GPCR Events, Meetings, and Webinars December 10 - 12, 2024 | Pharmacology 2024 January 13 - 16, 2025 | PepTalk 2025 January 25 - 29, 2025 | SLAS 2025 February 15 - 16, 2025 | Structural and Functional Approaches in GPCR Drug Discovery February 15 - 19, 2025 | BPS 2025 February 16 - 21, 2025 | Harnessing the Power of Advanced Multimodal Approaches to GPCR Drug Discovery March 12 - 14, 2025 | NextGen Biomed 2025 March 25 - 28, 2025 | 10th German Pharm-Tox Summit April 1 - 5, 2025 | XXIII GEM Meeting in 2025 April 3 - 6, 2025 | ASPET 2025 April 14 - 17, 2025 | 20th Drug Discovery Chemistry April 24 - 27, 2025 | American Physiology Summit 2025 April 25 - 30, 2025 | AACR Annual Meeting 2025 May 12 - 15, 2025 | PEGS 2025 May 20 - 22, 2025 | SLAS Europe 2025 June 16 - 19, 2025 | BIO International Convention 2025 July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology GPCR Jobs NEW Scientist - Biology Scientist I Cell Biology - Tectonic Therapeutic Senior Principal Scientist, Medicinal Chemistry PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial cell function Protein Biochemist/Structural Biologist GPCR Activation and Signaling Beyond the classic GPCR: unraveling the role of GPR155 role in cholesterol sensing and signaling High-affinity agonists reveal recognition motifs for the MRGPRD GPCR A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR Photo-BQCA: Positive Allosteric Modulators Enabling Optical Control of the M1 Receptor The cell adhesion molecule CD44 acts as a modulator of 5-HT7 receptor functions Signal profiles and spatial regulation of β-arrestin recruitment through Gβ5 and GRK3 at the μ-opioid receptor GPCR Binders, Drugs, and more Development of Macrocyclic Neurotensin Receptor Type 2 (NTS2) Opioid-Free Analgesics GPCRs in Cardiology, Endocrinology, and Taste Elucidating novel mechanism of action of spiperone for drug repurposing to prevent and treat murine colitis and sepsis GPCRs in Oncology and Immunology Pancreatic ductal adenocarcinoma, β-blockers and antihistamines: A clinical trial is needed Methods & Updates in GPCR Research PGxDB: an interactive web-platform for pharmacogenomics research GPCRdb in 2025: adding odorant receptors, data mapper, structure similarity search and models of physiological ligand complexes Reviews, GPCRs, and more Sensing host and environmental cues by fungal GPCRs Become a Premium Member! 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Phenylalanine 193 in Extracellular Loop 2 of the β 2-Adrenergic Receptor Coordinates β-Arrestin Interaction This single point mutation in extracellular loop 2 of the β2AR is sufficient to intrinsically bias the intracellular response to stimuli and suggests a previously undescribed role for the extracellular loops We characterized the effects of extracellular loop mutations on agonist-promoted interactions of GPCRs Our studies reveal that F193 in extracellular loop 2 in the β2-adrenergic receptor mediates interactions

on the web LinkedIn Endocrine Metabolic GPCRs Researchgate Twitter Imperial College London Elsevier Loop University of Birmingham Endocrine Metabolic GPCRs Society of Endocrinology Google Scholar ResearchGate Loop

Aylin Hanyaloglu on the web LinkedIn Researchgate Twitter Imperial College London Elsevier Loop Dr.

Françoise Bachelerie on the web INSERM ResearchGate SciSpace Loop LinkedIn Dr.