functional specificity at C-X-C chemokine receptor 5 (CXCR5) Panjamaporn Sangwung , Alejandra Tomas , Kyle Sloop , et al. for their outstanding study on Class B1 GPCRs: insights into multireceptor pharmacology

Phenylalanine 193 in Extracellular Loop 2 of the β 2-Adrenergic Receptor Coordinates β -Arrestin Interaction This single point mutation in extracellular loop 2 of the β 2AR is sufficient to intrinsically bias the intracellular response to stimuli and suggests a previously undescribed role for the extracellular loops We characterized the effects of extracellular loop mutations on agonist-promoted interactions of GPCRs Our studies reveal that F193 in extracellular loop 2 in the β2-adrenergic receptor mediates interactions

, three anti-parallel β-strands connected by 30s- and 40s-loops, and a C-terminal α-helix. bridges, which connect the N-loop to the 30s-loop and the β3-strand, thereby anchoring the distal N-terminus β3-strand align well, although the position of the disulfide bridges between the N-loop and the 30s-loop The 30s-loop of chemokines can bind either on top of the extracellular loop 2 (ECL2) or inside the major (ICLs 1-3) and three extracellular loops (ECLs 1-3).

Rueda, David J Chung, Heather J Landau, Oscar B Lahoud, Michael Scordo, Gunjan L Shah, Hani Hassoun, Kylee

on the web LinkedIn Endocrine Metabolic GPCRs Researchgate Twitter Imperial College London Elsevier Loop University of Birmingham Endocrine Metabolic GPCRs Society of Endocrinology Google Scholar ResearchGate Loop

Aylin Hanyaloglu on the web LinkedIn Researchgate Twitter Imperial College London Elsevier Loop Dr.