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pathway caused by BRS3 activation could induce the dephosphorylation and nucleus localization of the Yes-associated Authors Miao Guo , Yan Zhang , Lehao Wu , Ye Sheng , Jiaqi Zhao , Zeyuan Wang , Huiyu Wang , Lu Zhang

Authors Yi Tang, Ye Tian, Chun-Xia Zhang, Guo-Tai Wang Tags G Protein-coupled receptors , Olfactory receptors

I then pressed record, and we chatted for almost 2h about Bob’s career, discoveries, difficulties (yes

Authors Chunyang Yi, Jiacheng He, Dan Huang, Yumiao Zhao, Chan Zhang, Xiyun Ye, Ying Huang, Ruth Nussinov

phosphorylation at Tyr357, as shown by using the SFK inhibitors dasatinib, saracatinib, the preferential YES1 inhibitor CH6953755, siRNA-mediated knockdown of YES1, and transfection of epitogue-tagged YAP mutants , our results also demonstrate that exposure to SFK inhibitors, including dasatinib or knockdown of YES

In his Honours year, Brendan explored small molecule allosteric modulators of the β2-adrenoceptor under Brendan is now a final year PhD candidate in the Orphan Receptor Laboratory headed by Associate Professor

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Christoph Lange , Jan Rupp , Jan Heyckendorf , Karoline I Gaede , Howard Amital , Philip Rosenstiel , Yehuda

They worked on the interactome of yeast and mammalian Rab5 homologs including identification of Rab5

Areas under the curves (AUC) corresponding to one-, three- and five-year survival were 0.731, 0.765 and

granulocyte colony-stimulating factor, and mitoxantrone (CLAG-M) in a phase 1/2 trial of 81 adults aged ≤60 years One-year overall survival (OS) and EFS were 80% and 76%, without differences in MRD- CR rates, OS, or

These proteases have been visualized in recent years due to their contribution to the progression of

In recent years, investigators have described an increased rate of autoimmune comorbidities as evidenced

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cells may identify new opportunities for CKD therapeutics. " Authors Harmandeep Kaur , Veera Ganesh Yerra

SIGNIFICANCE STATEMENT: Human genetic variant/mutation information has expanded rapidly in recent years

extracellular ATP (e-ATP) and ADO effects on the TME poses challenges in identifying optimal treatment targets, yet

Here, we describe the most recent literature, with a primary focus on the past 5 years, on GPCR targets

Authors Junyi Liang , Mohamed Seghiri , Pradeep Kumar Singh , Hyeon Gyu Seo , Ji Yeong Lee , Yoonjung Jo , Yong Bhum Song , Chulo Park , Piotr Zalicki , Jae-Yeon Jeong , Won-Ki Huh , Niña G Caculitan ,

As part of the degree, she undertook a 1-year research-based placement at the Charles Perkins Centre Alastair Brown (Sosei Heptares), where she is currently a final year Ph.D. student.

the involvement of G-protein-coupled receptors (GPCRs) in cancer is growing, GPCR-based therapies are yet

GPCR Newsletter We want to bring you closer to what's happening in the GPCR world and yet want to avoid

understanding the mechanism of an enigmatic moonlighting function of OGT that had been described only a year John suggested starting preparations a year to two years ahead due to the time needed to develop ideas

Then I moved to the University of Oxford on a 4-year Wellcome Trust Scholarship in Neuroscience, through

GPCR Podcast << Back to podcast list Mark Schmeizl About Mark Schmeizl Mark leverages 30 years in various