Xiaoxia Li , Yanxia Jiang , Yujun Li , Hong Li , Lipeng Shang , Guilin Feng , Huhu Zhang , Ziyuan Xu , Lina Yang , Bing Li , Robert Chunhua Zhao Tags Autophagy , NSCLC , PKA-Hippo signaling pathway , Proliferation

cAMP/PKA/BNIP3L axis, thereby promoting the tumorigenesis and progression of CRC. " Authors Junwei Tang , Wen Peng , Jiangzhou Ji , Chaofan Peng , Tuo Wang , Peng Yang , Ji'ou Gu , Yifei Feng , Kangpeng Jin , Xiaowei Wang , Yueming Sun Tags GPCR , autophagy , growth , homology modeling , mitochondria.

Authors Kangjie Shen , Qiangcheng Wang , Lu Wang , Yang Yang , Min Ren , Yanlin Li , Zixu Gao , Shaoluan Zheng , Yiteng Ding , Jiani Ji , Chenlu Wei , Tianyi Zhang , Yu Zhu , Jia Feng , Feng Qin , Yanwen Yang

Authors Ahmad Raza , Meng-Chi Yen , Gangga Anuraga , Iram Shahzadi , Muhammad Waqar Mazhar , Hoang Dang Minh Xuan , Sanskriti Dey , Sachin Kumar , Adrian Wangsawijaya Santoso , Bianca Tobias William , Chih-Yang Wang Tags G-protein-coupled receptor (GPCR) , genome , glioblastoma , malignancy , molecular biomarker

Authors Jie Xiong , Yu-Ting Dai , Wen-Fang Wang , Hao Zhang , Chao-Fu Wang , Tong Yin , Shu Cheng , Hui-Juan Zhong , Shan-He Yu , Lu Jiang , Sheng-Yue Wang , Hai Fang , Rui-Hong Zhang , Yue Zhu , Hong-Mei Yi , Xu-Feng Jiang , Jia-Yi Chen , Li Wang , Peng-Peng Xu , Sai-Juan Chen , Wei-Li Zhao Tags CCR1 , Epstein-Barr

attenuate lung injury in coronavirus disease 2019 (COVID-19). " Authors Yishi Xie , Wenbin Kuang , Dawei Wang , Kai Yuan , Peng Yang Tags CXCR2 , CXCR2 antagonist , Cancer , Chronic obstructive pulmonary disease

in multiple cancers, and quantitative proteomic and RNA profiling of exosomes in human cancer cell lines demonstrate its ability to promote cancer cell motility. " Authors Yu Jin Lee , Kyeong Jin Shin , Hyun-Jun Jang Jin-Sun Ryu , Chae Young Lee , Jong Hyuk Yoon , Jeong Kon Seo , Sabin Park , Semin Lee , A Reum Je , Yang

Authors Claes Dahlgren, Huamei Forsman, Martina Sundqvist, Lena Björkman, Jonas Mårtensson Tags GPCR

Authors Yi Tang, Ye Tian, Chun-Xia Zhang, Guo-Tai Wang Tags G Protein-coupled receptors , Olfactory receptors

protein-coupled receptor (GPCR) that is implicated in different physiological pathways in the brain, and has been linked expression was significantly higher in the glioma tissues compared to the normal brain tissues, and was linked Chen , Renheng Zou , Yuhao Weng , Chengxiang Peng , Zhichao Xu , Jingbai Zhang , Xiaorui Liu , Xiao Pang , Yunxiang Ji , Degui Liao , Miaoling Lai , Huaidong Peng , Yanbin Ke , Zhaotao Wang , Yezhong Wang

Oncology and Immunology G protein-coupled receptors: A target for microbial metabolites and a mechanistic link gut microbiota act as ligands for specific human G protein-coupled receptors (GPCRs) and modulate a range

Immunology [1,2,4]Triazolo[1,5-c]pyrimidines as Tools to Investigate A3 Adenosine Receptors in Cancer Cell Lines Compound 20 has been tested on both A3 adenosine receptor positive cancer cell lines (CHO-A3AR transfected , THP1 and HCCT26) and in A3 negative cancer cell lines, showing no effect on the latter and a proliferative

Abstract "Phosphatase of regenerating liver 3 (PRL3) is a specific tumor antigen overexpressed in a broad range Amos Hong Pheng Loh , Min Thura , Abhishek Gupta , Sheng Hui Tan , Kelvin Kam Yew Kuan , Koon Hwee Ang , Khurshid Merchant , Kenneth Tou En Chang , Hui Yi Yon , Yong Chen , Mathew Hern Wang Cheng , Arjandas Mahadev , Matthew Chau Hsien Ng , Michaela Su-Fern Seng , Prasad Iyer , Pei Ling Chia , Shui Yen Soh

< GPCR News < GPCRs in Oncology and Immunology Functional Assessment of Cancer-Linked Mutations in Sensitive Identified intolerant residues with reported cancer-linked mutations RGS14-R173C/H and RGS4-K125Q/E126K These findings show that 3DMTR identified intolerant residues that overlap with cancer-linked mutations : Human genetic variant/mutation information has expanded rapidly in recent years, including cancer-linked ratio (3DMTR) to define regions of genetic intolerance in RGS proteins and prioritize which cancer-linked

Authors Jiamin Zhou, Xigan He, Weixing Dai, Qingguo Li, Zhen Xiang, Yixiu Wang, Ti Zhang, Weiqi Xu, Lu Wang, Anrong Mao Tags Ferroptosis , GPR37 , Lipid metabolism , SCD1 , p38 Source Contribute to the GPCR

The lung cancer cell line H1299-BRS3 was treated with MK-5046, an agonist of BRS3, for different durations Authors Miao Guo , Yan Zhang , Lehao Wu , Ye Sheng , Jiaqi Zhao , Zeyuan Wang , Huiyu Wang , Lu Zhang

Our findings highlight a microbial ligand-GPCR pair in ISCs, revealing a causal link between microbial Authors Chaoliang Li , Panrui Zhang , Yadong Xie , Shishan Wang , Meng Guo , Xiaowei Wei , Kaiguang Zhang , Dan Cao , Rongbin Zhou , Sheng Wang , Xinyang Song , Shu Zhu , Wen Pan Tags Enterococcus , IBD , ISCs

receptor (EGFR) belongs to the receptor tyrosine kinases family and overexpression of EGFR has been linked Authors Yue Xu , Zihan Quan , Yuting Zhan , Haihua Wang , Jiadi Luo , Weiyuan Wang , Songqing Fan Tags

Authors Hong Zeng , Li Cheng , De-Zhi Lu , Shuai Fan , Ke-Xin Wang , Li-Li Xu , Bin Cai , Mou-Wang Zhou , Jin-Wu Wang Tags Hypothalamo-pituitary-adrenal axis , Neuroendocrine immunomodulatory axis , Neuroinflammation

He introduced molecular pharmacology to a wide range of the company's GPCR projects and was able to initiate

Nitric acid (NO) inhibition was tested on the macrophage cell line RAW264.7. Authors Han Zhou, Tao Hou, Aijin Shen, Wenyi Yu, Liangliang Zhou, Wenjie Yuan, Wanxian Wang, Yumin Yao , Jixia Wang, Yanfang Liu, Xinmiao Liang Tags Benign prostatic hyperplasia , G-protein coupled receptor

run in the mountains, play with Tilly (a 9-year old retired greyhound), collecting mini shoes, and hang

end, her lab uses several computational structural biology tools and rational drug design approaches, ranging

Authors Dan Ye , Pu Wang , Lei-Lei Chen , Kun-Liang Guan , Yue Xiong Tags IRG1/ACOD1 , cancer , inflammatory

Hoyer , Andreas Glück , Martina Guggeis , Alexander Ossysek , Andre Küller , Derk Frank , Christoph Lange

Authors Meng Wang, Yong Han, Chao Zhang Source Contribute to the GPCR News Coming soon Become a Contributor

identified physiological hormones of such under characterized ‘orphan’ receptors and functional probes for a range

On average, the white cells studied expressed 160 receptor mRNAs (range, 123-206).