September 2022 "Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) lipids have been shown to stabilize In this work, we applied MD simulations supported by native mass spectrometry (nMS) to study lipid interactions We demonstrate how tail composition plays a role in modulating the binding of PI(4,5)P2 lipids to GCGR Specifically, we find the PI(4,5)P2 lipids to have a higher affinity toward the inactive conformation

cholesterol, a prominent component of the plasma membrane, limits the ability of GPCRs to scramble lipids This mechanism may explain the inability of GPCRs to scramble lipids at the plasma membrane."

September 2022 Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism calibrate glucagon-like peptide 1 (GLP-1) bioavailability, thereby regulating systemic glucose and lipid metabolism. -1R) is not required for enteroendocrine L cell GLP-1 secretion and glucose homeostasis nor for the metabolic

GPCRs in Oncology and Immunology GPR37 promotes colorectal cancer against ferroptosis by reprogramming lipid metabolism via p38-SCD1 axis Published date September 21, 2024 Abstract "Colorectal cancer (CRC) is metabolism, suppressing the level of reactive oxygen species, and mitigating ferroptosis. Mechanistic studies have shown that GPR37 modulates lipid metabolism in tumor cells by promoting SCD1 metabolism , SCD1 , p38 Source Contribute to the GPCR News Coming soon Become a Contributor Classified

is to develop GPCR-based drugs for the treatment of obesity and Type 2 Diabetes (T2D) by exploring metabolically immune cell GPCRs and their cross-talk with other insulin-sensitive tissues regulating glucose and lipid metabolism. Sai Prasad Pydi on the web Molecular Metabolism & Cell Signaling Laboratory Website Twitter.com Research

Functional annotation of GPR37 showed enrichment of ether lipid metabolism, fat digestion and absorption , and histidine metabolism.