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49 items found for "Lipid metabolism"
- GPR37 promotes colorectal cancer against ferroptosis by reprogramming lipid metabolism via p38-SCD1 axis
GPCRs in Oncology and Immunology GPR37 promotes colorectal cancer against ferroptosis by reprogramming lipid metabolism via p38-SCD1 axis Published date September 21, 2024 Abstract "Colorectal cancer (CRC) is metabolism, suppressing the level of reactive oxygen species, and mitigating ferroptosis. Mechanistic studies have shown that GPR37 modulates lipid metabolism in tumor cells by promoting SCD1 metabolism , SCD1 , p38 Source Contribute to the GPCR News Coming soon Become a Contributor Classified
- Ep 62 with Dr. Sai Prasad Pydi
is to develop GPCR-based drugs for the treatment of obesity and Type 2 Diabetes (T2D) by exploring metabolically immune cell GPCRs and their cross-talk with other insulin-sensitive tissues regulating glucose and lipid metabolism. Sai Prasad Pydi on the web Molecular Metabolism & Cell Signaling Laboratory Website Twitter.com Research
- GPR37 expression as a prognostic marker in gliomas: a bioinformatics-based analysis
Functional annotation of GPR37 showed enrichment of ether lipid metabolism, fat digestion and absorption , and histidine metabolism.
- Plenary Lecture | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
complex with β-arrestin-1 and CFTR at apical membrane of efferent ductulus to regulate the salt/water metabolism have decoded the mechanisms underlying recognition of fish oil (unsaturated fatty acids) and other lipids by GPCRs (Science 2023, Science Advance 2021, PNAS 2023, Nature Metabolism 2023), recognition of amine
- Ep 84 with Rosie Dawaliby
developed my expertise in the field of pharmacology and biochemistry of GPCR and the crucial role of the lipidic discovery targeting GPCR ( Confo Therapeutics ) as a team and project leader for antibody discovery for metabolic
- TIPE proteins control directed migration of human T cells by directing GPCR and lipid second messenger signaling
Oncology and Immunology TIPE proteins control directed migration of human T cells by directing GPCR and lipid
- Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses in sterile and infectious inflammation
Loss of Gpr101 on macrophages was also associated with a significant disruption in their cellular metabolism These observations were linked with a marked dysregulation in peritoneal lipid mediator concentrations
- From outside to inside and back again: the lysophosphatidic acid-CCN axis in signal transduction
Lysophosphatidic acid (LPA) is a lipid that activates G protein-coupled receptors (GPCRs), enhancing There are multiple examples of the induction of CCN proteins by LPA, and by the related lipid mediator
- CaaX-motif-adjacent residues influence G protein gamma (Gγ) prenylation under suboptimal conditions
Prenyltransferases tether isoprenoid lipids to proteins via a thioether linkage during prenylation. Pharmacological inhibition of the lipid synthesis pathway by statins is a therapeutic approach to control
- Ep 52 with Dr. Benjamin Myers
These studies have revealed new and unexpected ways for membrane lipids to regulate GPCR activity and
- GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment
This acidification is the result of altered tumor metabolism favoring aerobic glycolysis, a phenomenon finding was further validated by transmission electron microscopy and liperfluo staining to assess lipid
- A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis
U251 glioblastoma cells by enhancing signaling mediated by sphingosine-1-phosphate (S1P), a bioactive lipid
- Gi/o GPCRs drive the formation of actin-rich tunneling nanotubes in cancer cells via a Gβγ/PKCα/FARP1/Cdc42 axis
governing the generation of specialized actin-rich elongated structures in response to bioactive signaling lipids
- C5aR2 receptor: The genomic twin of the flamboyant C5aR1
Authors Aurosikha Das, Pulkit K Gupta, Soumendra Rana Tags C5a; C5aR2/C5L2 receptor; lipid bilayer; molecular
- Ep 155 with Endocrine Metabolic GPCR Organizers
GPCR Podcast << Back to podcast list Re-cap of Endocrine Metabolic GPCR 2024 with the Organizers About Aylin Hanyaloglu on the web LinkedIn Endocrine Metabolic GPCRs Researchgate Twitter Imperial College Her current research focuses on how metabolic GPCRs cross-talk and interact to regulate appetite and bone metabolism." Caroline Gorvin on the web University of Birmingham Endocrine Metabolic GPCRs Society of Endocrinology
- Pharmacological and Genetic Preclinical Models of Ghrelin Receptor Functional Selectivity to Investigate Metabolic Disease Pathophysiology
Pharmacological and Genetic Preclinical Models of Ghrelin Receptor Functional Selectivity to Investigate Metabolic in exploiting GPCR biased signaling to design/develop new pharmacotherapeutics to treat reward- and metabolism-based is to better understand the underlying mechanisms of food reward and its downstream dysregulation of metabolic develop novel GPCR pharmacotherapies that improve efficacy and minimize side effects for diet-induced metabolic
- Itaconate in host inflammation and defense
inflammation and defense Published date March 5, 2024 Abstract "Immune cells undergo rapid and extensive metabolic In addition to contributing to energetic and biosynthetic demands, metabolites can also function as signaling This metabolite binds to and regulates the function of diverse proteins intracellularly to influence metabolism, oxidative response, epigenetic modification, and gene expression and to signal extracellularly In this article, we review ITA metabolism and its regulation, discuss its target proteins and mechanisms
- Ep 143 with Dr Davide Calebiro
Calebiro is Chair of Molecular Endocrinology and Wellcome Trust Senior Research Fellow at the Institute of Metabolism Stockholm, and obtained a PhD in Molecular Medicine and a Clinical Specialisation in Endocrinology and Metabolic basic mechanisms of G protein-coupled receptor (GPCR) signalling and their alterations in endocrine, metabolic
- Metabolic crosstalk: Extracellular ATP and the tumor microenvironment in cancer progression and therapy
< GPCR News < GPCRs in Oncology and Immunology Metabolic crosstalk: Extracellular ATP and the tumor microenvironment This review explores e-ATP metabolism, its purinergic signaling, and therapeutic strategies targeting
- Ep 153 with Dr Jacek Mokrosiński
studying structural and mechanistic properties of ghrelin receptor and GPCRs involved in regulation of metabolism After completing his Ph.D., he pursued research in genetics of metabolic regulation at the Institute of Metabolic Science - Metabolic Research Laboratories at the University of Cambridge in the team led series of novel human genetic variants identified in several GPCRs associated with obesity and other metabolic
- Illuminating Functional Selectivity and Allosterism at GPCRs.
Laporte is a Professor of Medicine, and the Director of Research of the Division of Endocrinology and Metabolism He is also an Associate Leader of the Experimental Therapeutics and Metabolism Program and the Director
- Ep 142 with Dr Claudia Stäubert
Nordström (Umeå, Sweden), I broadened my methodical and scientific horizon and focused on cellular metabolism Our ultimate goal is to understand their role in immune cell function and cancer cell metabolism. " Dr Yamina expressed interest in attending a meeting about GPCRs and metabolism in the UK, but was unsure Metabolite Activation of GPCRs: A Fascinating Discovery Claudia and Yamina discussed the role of metabolites example she heard in a podcast about fecal transplants and the relationship between the gut, brain, and metabolism
- Glucose and HODEs regulate Aspergillus ochraceus quorum sensing through the GprC-AcyA pathway
Furthermore, GprC and AcyA regulate the primary metabolism as well as secondary metabolism, and further
- Using food perception and bioamine signaling networks to slow aging
laboratory is focused on the molecular mechanisms of aging, with an emphasis on stress response and metabolism
- Ep 105 with Annabelle Milner
placement at the Charles Perkins Centre in Sydney, investigating the effects of dietary carbohydrates on metabolic Annabelle’s Ph.D. work focuses on microbial-derived metabolites that signal through GPCRs expressed in
- Ep 79 with Dr. Graeme Milligan
Milligan is the co-founder of both Caldan Therapeutics (2015) which discovers novel therapeutics for metabolic
- Ep 96 with R. Scott Struthers
Prior to Crinetics, he was senior director and head of endocrinology and metabolism at Neurocrine Biosciences
- Receptor autoantibodies: Associations with cardiac markers, histology, and function in human non-ischaemic heart failure
healthy controls and tested associations of serum autoantibody levels with serological, haemodynamic, metabolic However, they are correlated poorly or even inversely to haemodynamic, metabolic, and functional markers