< GPCR News < GPCRs in Oncology and Immunology Deciphering the genetic landscape of lumpy skin disease virulence through comprehensive genome sequence analysis in India Published date May 23, 2024 Abstract "Lumpy Skin Disease (LSD), a poxvirus disease affecting cattle, emerged in India in 2019 and intensified in Sai Balaji, V Gairola, D Poloju, S Gulzar, K P Singh, R K Singh, G K Sharma Tags Genome sequence , Lumpy skin disease , Molecular diversity , Virulence Source Contribute to the GPCR News Coming soon Become

pathogenesis via amplifying IL-23/IL-17 axis signal pathway Published date September 10, 2024 Abstract "Skin psoriasis is defined as receiving external stimulation to activate skin dendritic cells (DCs) which knockout (K14-cKO) mice models to explore the function of GPR97 which influences keratinocytes and skin disease and restricted HaCaT cells abnormal proliferation as well as Th17 cells differentiation. GPR97 is indispensable and this adhesion receptor may affect immune cell enrichment and function in skin

Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms and therapeutic targets in atopic diseases The consequences of altered neuroimmune activity differ with tissue type and disease and include: skin neuroimmune interactions that underlie the various sensory and autonomic pathologies in type 2 inflammatory diseases in targeted treatment approaches to reduce type 2 inflammation and its associated symptoms in these diseases CSU , Calcitonin gene-related peptide , Chronic idiopathic urticaria , Chronic obstructive pulmonary disease

News < GPCRs in Oncology and Immunology GPCRs and fibroblast heterogeneity in fibroblast-associated diseases About one-third of the commercially available drugs for various diseases target the GPCRs. Understanding the dynamics of GPCR signaling in fibroblasts with disease progression can help in the recognition of the complex interplay of different GPCR subtypes in fibroblast-mediated diseases. Apar K Ganti , Surinder K Batra , Maneesh Jain Tags GPCR signaling , fibroblast behavior , fibrotic diseases

Immunology CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases This pathway is implicated in mechanisms related to many diseases, such as cancer, psoriasis, multiple This review highlights the potential as a therapeutic target of the CCR6 receptor in numerous diseases

Retreat Program < Back to schedule Cannabinoid compounds to augment L-DOPA treatment in Parkinson's Disease

and Immunology Expanding role of CXCR2 and therapeutic potential of CXCR2 antagonists in inflammatory diseases receptor 2 (CXCR2) is G protein-coupled receptor (GPCR) and plays important roles in various inflammatory diseases and cancers, including chronic obstructive pulmonary disease (COPD), atherosclerosis, asthma, and pancreatic a new target for diabetes and that CXCR2 antagonists may also attenuate lung injury in coronavirus disease (COPD) , Coronavirus disease 2019 (COVID-19) , Inflammatory disease.

Program < Back to schedule Biased agonism at the GLP-1 receptor: from structure to animal models of disease

Sponsors GPCR Retreat Program < Back to schedule Genetic Deletion of Atypical VGLUT3 Rescues Huntington’s Disease coupled receptors and their role in neurodegenerative disorders, including Alzheimer's and Huntington's diseases

Portal Venous Blood as a Possible Mechanism for Microbiota Effects on the Immune System, and Western Diseases pro-inflammatory immune cells may travel to tissues such as the brain, the lung, the kidney etc and promote disease how the gut microbiome may be affecting peripheral immune cells, and consequently Western lifestyle diseases Authors Quanbo Wang , Charles R Mackay Tags Gut microbiota , Western lifestyle diseases , portal vein

and Genetic Preclinical Models of Ghrelin Receptor Functional Selectivity to Investigate Metabolic Disease GPCR biased signaling to design/develop new pharmacotherapeutics to treat reward- and metabolism-based diseases novel GPCR pharmacotherapies that improve efficacy and minimize side effects for diet-induced metabolic diseases

of studying metabolites and their receptors, the relationship between metabolites, gut health, and disease They briefly touched upon the link between GPCRs and diseases, such as diabetes, but did not delve into Metabolites, Gut Health, and Disease Progression Yamina and Claudia had a discussion about the relationship between metabolites, gut health, and disease progression. Both agreed on the complexity of the topic, with Claudia concluding that diseases might first affect

23, 2022 Abstract Due to its high metastatic potential, malignant melanoma is one of the deadliest skin

reaction networks are an important and emerging tool for the study of cell signaling networks involved in disease One promising potential application of such mathematical models is the study of how disease-causing mutations promote the signaling phenotype that contributes to the disease. and use model-driven explorations to uncover and explore multiple new areas for investigating this disease revealed the potential for previously unknown qualitative differences between seemingly interchangeable disease-promoting

Despite advances in the treatment, many patients experience disease relapse or become refractory to treatment Authors Jihong Jeong, Junhyeon Park, Geun Young Mo, Jinwoo Shin, Yunje Cho Tags GPRC5D , Multiple myeloma

Exosomes transport a variety of macromolecules and modulate intercellular communication in physiology and disease proteome and demonstrate its ability to promote cancer cell motility. " Authors Yu Jin Lee , Kyeong Jin Shin

However, the physiological functions of many GPCRs and the involvement of them in autoimmune diseases However, Gpr141 deficiency exacerbated disease conditions of experimental autoimmune encephalomyelitis , an autoimmune disease model for multiple sclerosis, with increased inflammation in the spinal cord. that targeting GPR141 may be a possible therapeutic intervention for modulating chronic inflammatory diseases Okazaki, Akira Nakamura, Ryo Goitsuka, Tomonori Kaifu Tags G protein–coupled receptor 141 , autoimmune disease

Indian Institute of Science, Bangalore, India, to investigate the mechanisms behind rare mitochondrial diseases at the Cleveland Clinic in Ohio, USA, studying the gut microbiome and its impact on cardiovascular disease gut microbe-derived metabolite called phenylacetylglutamine (PAG), which is linked to cardiovascular disease as targets for more than one-third of all prescribed drugs currently used in the treatment of human diseases

Administration of ITA protects against inflammatory diseases and blockade of ITA production enhances mechanisms, and conjecture a rationale for developing ITA-based therapeutics to treat inflammatory diseases Dan Ye , Pu Wang , Lei-Lei Chen , Kun-Liang Guan , Yue Xiong Tags IRG1/ACOD1 , cancer , inflammatory diseases

Among 41 patients treated at RP2D, a measurable residual disease-negative complete remission (MRD- CR 76%, without differences in MRD- CR rates, OS, or EFS between patients with or without FLT3-mutated disease Benefit was limited to patients with intermediate-risk disease (univariate analysis: P = .01 for OS; improves OS and EFS relative to CLAG-M alone, with benefits primarily in patients with intermediate-risk disease

mechanisms underlying biased agonism at GPCRs and its contribution inflammation and cardiovascular disease His clinical focus is on pulmonary arterial hypertension, a disease of the pulmonary arterioles that causes right heart failure, and he serves as co-director of the Duke Pulmonary Vascular Disease Center

compounds in Jinqiancao granules and their target mechanisms for the potential treatment of the two diseases networking were utilized to establish a general correlation between Jinqiancao granules and the two diseases Five compounds showed weak antagonistic activity on M3, which was confirmed to be a disease target by experiment-based network reflected a pharmacological relationship between Jinqiancao granules and the two diseases

the Receptor Biology Lab, focuses on the development of novel GPCR-based therapeutics that interdict diseases basis of a new technology-based start-up company, HeptOME , to help screen and develop novel longevity/disease-regulating compounds with multidimensional disease efficacy profiles.

the Receptor Biology Lab, focuses on the development of novel GPCR-based therapeutics that interdict diseases basis of a new technology-based start-up company, HeptOME , to help screen and develop novel longevity/disease-regulating compounds with multidimensional disease efficacy profiles.

the Receptor Biology Lab, focuses on the development of novel GPCR-based therapeutics that interdict diseases basis of a new technology-based start-up company, HeptOME , to help screen and develop novel longevity/disease-regulating compounds with multidimensional disease efficacy profiles.

the co-founder of both Caldan Therapeutics (2015) which discovers novel therapeutics for metabolic diseases Type 2 Diabetes and other indications including non-alcoholic steatohepatitis (NASH) and inflammatory diseases

curated the major advances in understanding GPCR biology and moving closer to targeting receptors in diseases

While GPR4 deficiency did not show major alterations in disease progression, OGR1 KO mice had higher setting of oxalate-induced nephropathy, the lack of the proton-activated GPCR GPR4 does not influence disease Wagner , Pedro Henrique Imenez Silva Tags G-protein-coupled receptors , acid-base , chronic kidney disease