September 2022 Regulator of G Protein Signaling 20 Correlates with Long Intergenic Non-Coding RNA (lincRNAs be an important factor for survival in four other cancers (clear renal cell carcinoma: p < 0.001, lung adenocarcinoma: p = 0.004, mesothelioma: p = 0.039, ovarian serous cystadenocarcinoma: p = 0.048) ; (d) RGS20 was found to be significantly associated with some tumor-related signaling pathways and long

Our genomic analysis showed that GRK3 expression correlated with poor prognosis of gastric adenocarcinoma

GPCRs in Oncology and Immunology A2aR on lung adenocarcinoma cells: A novel target for cancer therapy

Juan Jose Fung, Principal Scientist, at GPCR Therapeutics.

October 2022 "Systolic heart failure (HF) is a chronic clinical syndrome characterized by the reduction in cardiac function and still remains the disease with the highest mortality worldwide. Despite considerable advances in pharmacological treatment, HF represents a severe clinical and social burden. Chronic human HF is characterized by several important neurohormonal perturbations, emanating from both the autonomic nervous system and the adrenal glands. Circulating catecholamines (norepinephrine and epinephrine) and aldosterone elevations are among the salient alterations that confer significant hormonal burden on the already compromised function of the failing heart. This is why sympatholytic treatments (such as β-blockers) and renin-angiotensin system inhibitors or mineralocorticoid receptor antagonists, which block the effects of angiotensin II (AngII) and aldosterone on the failing heart, are part of the mainstay HF pharmacotherapy presently. The adrenal gland plays an important role in the modulation of cardiac neurohormonal stress because it is the source of almost all aldosterone, of all epinephrine, and of a significant amount of norepinephrine reaching the failing myocardium from the blood circulation. Synthesis and release of these hormones in the adrenals is tightly regulated by adrenal G protein-coupled receptors (GPCRs), such as adrenergic receptors and AngII receptors. In this review, we discuss important aspects of adrenal GPCR signaling and regulation, as they pertain to modulation of cardiac function in the context of chronic HF, by focusing on the 2 best studied adrenal GPCR types in that context, adrenergic receptors and AngII receptors (AT 1 Rs). Particular emphasis is given to findings from the past decade and a half that highlight the emerging roles of the GPCR-kinases and the β-arrestins in the adrenals, 2 protein families that regulate the signaling and functioning of GPCRs in all tissues, including the myocardium and the adrenal gland." Read more at the source #DrGPCR #GPCR #IndustryNews

immunothrombosis has become more relevant than ever, as a majority of COVID-19 patients display thrombi in the lung Furthermore, NETs can be found in the lung and other tissues and are associated with an increased mortality cytokine storm that potently activates neutrophils and leads to massive neutrophil infiltration into the lung

and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy "Pancreatic ductal adenocarcinoma

Pulmonary Fibrosis "Idiopathic pulmonary fibrosis (IPF) is a disease characterized by irreversible lung We demonstrate that OGR1 protein expression is significantly reduced in lung tissue from patients with

In a LPS-induced lung inflammation model in mice, ACT-660602 led to significantly reduced recruitment

TGR5 is widely distributed in the brain, lung, heart, liver, spleen, pancreas, kidney, stomach, jejunum

human islets AT2 receptor agonist LP2 restores respiratory function in a rat model of bleomycin-induced lung G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung

analyses, have indicated that OR genes are also expressed in non-olfactory tissues including the testis, lung In non-small-cell lung cancer OR2J3 activation induced apoptosis and inhibited cell proliferation and migration in long-term stimulus experiments (Kalbe B. et al. 2017).

Immunology Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung

patients with WHIM syndrome Bristol Myers Squibb’s Investigational LPA1 Antagonist Reduces the Rate of Lung

disorder GPCRs in Oncology and Immunology Regulator of G protein signaling protein 6 alleviates acute lung

DRD1 is exempt from TGFβ-mediated antifibrotic GPCR landscape tampering in lung fibroblasts. βHB inhibits

Transforming Growth Factor β-Mediated Antifibrotic G Protein-Coupled Receptor Landscape Tampering in Lung

prefrontal cortex cells and circuits GPCRs in Oncology and Immunology RGS20 promotes non-small cell lung

$4.6 Million in Milestone Payments from Centessa Pharmaceuticals CB1 receptor inverse agonist improves lung

Photopharmacology GPCRs in Cardiology, Endocrinology, and Taste Rap1A Modulates Store-Operated Calcium Entry in the Lung

1984 (Cerione et al. 1984), where reconstitution of purified β2-adrenergic receptors from guinea pig lung

Don’t be surprised if you find yourself singing Daddy Yankee’s “Gasolina” from the top of your lungs

Our results reveal that the extended N-terminus of the long isoform limits G protein activation yet elevates constitutive G13 activation, while an additional cysteine contributed by the extended N-terminus of the long

GPCRs have been long considered as controllers of communication between tissues and cells. receptorsomes, both at the cell surface membrane and in the intracellular domain dictate and condition long-term

Here, we investigate the effects that long-term CNO stimulatory culture have on hM3Dq [Ca2+]i signaling Long-term culturing under repeated CNO stimulation modified the temporal dynamics of hM3Dq [Ca2+]i signaling

adopted to elucidate the structure, pharmacology, and signaling of cardiovascular GPCRs, resolving long-standing

Sir William Osler Scientists have long sought to discover a “golden bullet” that would cure every disease signal-regulated kinases (ERK), a subset of the mitogen-activated protein kinase (MAPK) family, have long

disease before they can even dare to contemplate the development of therapeutic options and begin the long