< GPCR News < GPCRs in Oncology and Immunology A2aR on lung adenocarcinoma cells: A novel target for Here, we identify that A2aR is specifically expressed on tumor cells from lung adenocarcinoma (LUAD) Tags A2aR , Lung adenocarcinoma , Migration , Polarization , Targeted therapy , Tumor-associated macrophages

Immunology Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung Published date July 3, 2023 Abstract "Despite campaigns and improvements in detection and treatment, lung One approach to treating patients suffering from lung cancer is to target surface receptors overexpressed Since lung cancer is often diagnosed in advanced stages, our efforts should focus on early diagnosis, Furthermore, their modulation could be considered as a promising approach in lung cancer therapeutics

News < GPCRs in Oncology and Immunology Regulator of G protein signaling protein 6 alleviates acute lung protein-coupled receptor (GPCR)-related genes and differentially expressed genes (DEGs) in an acute lung RGS6 plays a protective role in ALI not only in early inflammatory responses but also in endogenous lung Li , Cuicui Chen , Jian Zhou , Linlin Wang , Yu Yan , Jun She , Lin Tong , Yuanlin Song Tags Acute lung

Transforming growth factor-β (TGFβ) is essential for alveologenesis and lung repair, and the G protein To understand the role of mesenchymal Gαq/11 in lung development, we generated constitutive (Pdgfrb-Cre suppressed myofibroblast differentiation, altered mesenchymal cell synthetic function, and reduced lung TGFβ2 signalling in mesenchymal cells, which is imperative for normal alveologenesis and maintenance of lung Tags Alveologenesis , Cyclical mechanical stretch , GPCR , Gαq/11 , Lung development , TGFβ .

In gene expression analysis of mouse lungs with induced fibrosis, eight GPCRs were identified, showing actin (αSMA), the profibrotic factor transforming growth factor β1 (TGFβ1), and collagen in a human lung Similar to the lung fibrosis model, increased Gpr176 expression was also observed in other organs affected expressed Gpr176 compared to alveolar epithelial cells, endothelial cells, and macrophages in the fibrotic lung

Mesothelioma and lung cancer induced by exposure to carcinogenic (e.g., certain asbestos) fibers in humans This theory is reviewed, implications of this theory are discussed in relation to mesothelioma and lung Author Kenneth T Bogen Tags Asbestos , Cytotoxicity , Inflammation , Lung cancer , Mesothelioma , Mutation

Druey at NIAID/NIH, where I characterized the role of RGS4 and RGS5 in airway hyperresponsiveness and lung fascinated by the multitude of processes that are regulated/dysregulated by GPCRs and RGS proteins in the lungs

Monserrat Avila Zozaya "My doctoral research was focused on investigating the cellular effects of missense lung

dynamics was performed for tumor-nodes-metastases (TNM) defined subgroups (ovarian and hepatocellular adenocarcinomas

p38 signaling responses we are studying how atypical p38 controls the onset and pathogenesis of acute lung

Single-cell RNA sequencing on long-bone stromal cells of 9-wk-old male ColI(2.3)+/Rs1+ mice and littermate Authors Hsuan Lung, Kelly L Wentworth, Tania Moody, Ariane Zamarioli, Apsara Ram, Gauri Ganesh, Misun

Such pro-inflammatory immune cells may travel to tissues such as the brain, the lung, the kidney etc

be used as a biomarker and a new target for diabetes and that CXCR2 antagonists may also attenuate lung

The lung cancer cell line H1299-BRS3 was treated with MK-5046, an agonist of BRS3, for different durations

During that time, I investigated the effect of lung cancer-related mutations in the GAIN domain of the My long-term interest is focused on understanding the mechanisms mediated by GPCRs at the cellular communication

Monserrat Avila Zozaya "My doctoral research was focused on investigating the cellular effects of missense lung

< GPCR News < GPCRs in Oncology and Immunology Severity of neurological long-COVID symptoms correlates The pathogenesis of Long-COVID is currently under heavy scrutiny and existing data on the role of auto-immune moderate SARS-CoV-2 infection up to 12 months prior to enrollment with (n = 72) or without (n = 58) Long-COVID Results: The prevalence and concentrations of evaluated autoantibodes were significantly higher in Long-COVID significantly higher number of patients with simultaneous detection of more than one autoantibody in Long-COVID

Authors Ze Wu , Qiongqiong Jia , Boqun Liu , Lanlan Fang , Peter C K Leung , Jung-Chien Cheng Tags Invasion

the crystal structure of the beta2-adrenergic receptor (beta2AR)-G protein complex, team effort with long question regarding the signaling differences in G protein splice forms, specifically the short and long Galpha-s(l), but not Galpha-s(s), regulates extracellularly regulated kinases (ERK), and that this long optimize its potential as a treatment for cocaine abuse, a debilitating disease that would require long-term

Authors Zhenyu Yao, Jun Meng, Jing Long, Long Li, Weicong Qiu, Cairong Li, Jian V Zhang, Pei-Gen Ren

My long-term research interests involve resolving signaling pathways downstream of aGPCRs and establishing

The long-term goal of Dr. GPCR About Anne Marie Quinn "Anne Marie Quinn has a long and varied work experience in the biocomputing Prior to that, they obtained a Bachelor of Arts (B.A.) degree from California State University, Long

Hoyer , Andreas Glück , Martina Guggeis , Alexander Ossysek , Andre Küller , Derk Frank , Christoph Lange

However, a new study suggests that long-term use of P2Y12R inhibitors may increase the risk of cancer

Our laboratory has a long-standing interest in the way that NMDA receptors contribute to the symptoms

My long-term plan is to conduct research in the field of receptor biology, with a focus on GPCRs.

Lange and Annie Mary Lyle Chair in Cardiovascular Research, and Professor of Pharmacology, Ophthalmology

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