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20 items found for "M2 macrophages"
- G protein-coupled receptor 21 in macrophages: An in vitro study
GPR21 couples to the Gq family of G proteins and is expressed in macrophages. Studies of GPR21 knock-out mice indicated that GPR21 may be involved in promoting macrophage migration The aim of this study was to evaluate the role of GPR21 in human macrophages, analyzing (i) its involvement THP-1 cells were activated and differentiated into either M1 or M2 macrophages. Cell migration was detected by the Boyden chamber migration assay, performed on macrophages derived from
- Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of...
September 2022 Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model As tumor-associated macrophages (TAMs) serve as major contributors to the immuno-suppressive tumor microenvironment We show that through proper calibration, the model captures the macrophage heterogeneity in the tumor
- Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation...
September 2022 Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation Autophagy deficiency in myeloid cells plays a causal role in eosinophilic CRS (ECRS) via macrophage IL autophagy‐enhancing agent, trehalose, or related sugar compounds, and the underlying mechanism focusing on macrophage Methods We investigated the therapeutic effects of trehalose and saccharin on macrophage IL‐1β production
- Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 1
expression has been directly challenged by a publication purporting ACKR1 expression in mouse BM by macrophages , but not erythroblasts and ECs, suggesting that macrophage ACKR1 engages its non-cognate ligand CD82 The reported ACKR1 expression by macrophages in Hur et al. relied on using commercial anti-ACKR1 antibody prompted us to investigate the specificity of FAB6695 and scrutinize the apparent ACKR1 expression in BM macrophages
- GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation
GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages expressed in myeloid cells that constitute the innate immune system, including neutrophils, monocytes, and macrophages Infiltrating GPR84+ macrophages are significantly increased in the colonic mucosa of both the UC patients activation, while the loss of GPR84 prevents the M1 polarization and properties of proinflammatory macrophages discovered by us, suppresses colitis by reducing the polarization and function of pro-inflammatory macrophages
- Dimerization of GPCRs: Novel insight into the role of FLNA and SSAs regulating SST2 and SST5...
/SST5 dimerization in rat GH3 as well as in human melanoma cells either expressing (A7) or lacking (M2 First, we observed the formation of endogenous SST5 homo-dimers in GH3, A7, and M2 cells. the PLA approach combined with epitope tagging, we detected homo-dimers of human SST2 in GH3, A7, and M2 A7), and octreotide but not pasireotide promoted hetero-dimerization in both A7 and M2 (+20.0 ± 11.8% and +44.1 ± 16.3% increase of PLA events in A7 and M2, respectively, P < 0.05 vs . basal).
- 📰 GPCR Weekly News, June 3 to June 9, 2024
Jürgen Wess and Liu Liu for their study on A novel function of the M2 muscarinic receptor Drs. protein-coupled receptor variants in the hypothalamic-pituitary-gonadal axis1 A novel function of the M2
- Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi...
Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages "The fungal pathogen Histoplasma capsulatum (Hc) invades, replicates within, and destroys macrophages We demonstrated that whereas C3aR is dispensable for macrophage phagocytosis of bacteria and latex beads , it is critical for optimal macrophage capture of pathogenic fungi, including Hc, the ubiquitous fungal and uncover a novel and specific role for C3aR in macrophage recognition of fungi."
- CD28 and chemokine receptors: Signalling amplifiers at the immunological synapse
September 2022 "T cells are master regulators of the immune response tuning, among others, B cells, macrophages
- N-Acyl Amides from Neisseria meningitidis and Their Role in Sphingosine Receptor Signaling
Both groups of metabolites suppress anti-inflammatory interleukin-10 signaling in human macrophage cell
- Computational study of the conformational ensemble of CX3C chemokine receptor 1 (CX3CR1) and its...
participate in the activation, chemotaxis and recruitment of multiple immunological cells such as microglia, macrophages
- Nanobodies: New Dimensions in GPCR Signaling Research
Nb9-8: This nanobody was identified for the M2 muscarinic receptor (M2R) and increased the affinity of
- 📰 GPCR Weekly News, May 6 to 12, 2024
sustained spiking in brainstem parabrachial neurons to suppress feeding The C-terminus of the prototypical M2
- Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled ..
Several members of MRGPRs are also expressed in mast cells, macrophages, and in cardiovascular tissue
- 📰 GPCR Weekly News, November 13 to 19, 2023
induces STAT3/HIF-1α/IL-22 signaling via GPCR and HDAC3 inhibition to activate autophagy in head kidney macrophages
- 📰 GPCR Weekly News, December 11 to 17, 2023
shining light on signaling pathways GPCRs in Oncology and Immunology Leukotriene B4 receptor 2 governs macrophage
- 📰 GPCR Weekly News, May 29 to June 4, 2023
adenocarcinoma cells: A novel target for cancer therapy via recruiting and regulating tumor-associated macrophages
- Unlock the Future of GPCR Science: Breakthroughs and Courses Await | Sep 2 - Sep 8, 2024
metabolite-GPCR axis is associated with microbial dysbiosis in IBD patients: Potential role of GPR109A in macrophages
- 📰 GPCR Weekly News
Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses
- Adhesion GPCR Consortium Newsletter - May 2024
PMID: 38412860 GPR133 is hypomethylated and upregulated in decidual macrophages in recurrent spontaneous