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15 results found for "Madelyn Moore"

Posts (9)

  • VAMP2: a crucial player in the delivery of MOR to the synapse

    VAMP2 can interact with other GPCRs, such as the beta-2 adrenergic receptor and the mu-opioid receptor (MOR this technology, they evidenced the presence of VAMP2, specifically in recycling vesicles containing MOR These data are fascinating because in the case of MOR, which is a receptor with several splicing variants modulated by different opioids, either endogenous or exogenous, promoving a differential organization of MOR Since MOR receptor regulates pain perception and reward, the dysfunction in the MOR-SNARE complex interaction

  • New role of β-arrestins in MOR signaling

    EOPs): β-endorphin, enkephalins and dynorphins, and four opioid receptors (ORs): μ-opioid receptor (MOR Morphine is an agonist of Mu opioid receptor (MOPR) and one of the objectives in the development of new Therefore to understand better the functions of arrestins in MOR signaling, Shiraki et al., explored the function of β-arrestin 2 in MOR signaling using the SH-SY5Y cell line that endogenously expresses MOR and was modified through CRISPR/Cas9 to knock out β-arrestin 1 and 2 gene expression.

  • GRK3 is a poor prognosticator and serves as a therapeutic target in advanced gastric adenocarcinoma

    Our genomic analysis showed that GRK3 expression correlated with poor prognosis of gastric adenocarcinoma

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