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October 2022 Increased Anxiety-like Behaviors in Adgra1-/- Male But Not Female Mice are Attributable We found that Adgra1-/- male but not female mice exhibited elevated anxiety levels in the open field, complexity and spine density as evidenced by elevated expression levels of SYN and PSD95 in amygdalae of male activated when compared to wt male mice. control and synaptic function by regulating the PI3K/AKT/GSK-3β and MEK/ERK pathways in amygdalae of male

The present study aims to investigate the possible role of FSH excess in male bone health, by comparing

2022 PLC-IP3-ORAI pathway participates in the activation of the MRGPRB2 receptor in mouse peritoneal mast cells "A novel mast cell-specific G-protein-coupled receptor (GPCR), known as Mas-related G protein-coupled results indicated the involvement of the PLC-IP3-ORAI signaling pathway and CACCS in MRGPRB2-mediated mast

Completion of cytokinesis in the presence of pheromone is promoted by the kelch-repeat protein, Kel1 We found that RGS complexes with Kel1 and prefers the unphosphorylatable RGS mutant. unphosphorylatable RGS exacerbates cytokinetic defects, whereas they are rescued by overexpression of Kel1 These data lead us to a model where Kel1 promotes completion of cytokinesis before pheromone-induced

pharmacology is derived from rodent models, but most of this preclinical research has only focused on male of DOI on head-twitch behavior (HTR) - a mouse behavioral proxy of human psychedelic potential - in male DOI elicited more HTR in female as compared to male C57BL/6J mice, a sex-specific exacerbated behavior Volinanserin (or M100907) - a 5-HT2AR antagonist - fully prevented DOI-induced HTR in male and female plasma concentrations of DOI were lower 30 and 60 min after drug administration in female as compared to male

The expression levels of the two genes were different between male and female adults, and there were

characteristics with the 2 cases we previously reported as follows: (a) elderly (74-87 years at diagnosis), (b) male

impact delta and kappa opioid receptor-mediated synaptic depression in dorsolateral striatum of adult male

We demonstrate in male and female rats that GABAB receptors receptors alter Pr, whereas 5-HT1B receptors

Treatment from KBP Biosciences Exscientia to Present New Preclinical Data for AI-designed LSD1 and MALT1

serum metabolomic assessment reveals systemic implications of acute ozone-induced stress response in male

Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions GPCRs in Neuroscience Male-specific

Transcriptome profiling of male and female Ascaris lumbricoides reproductive tissues.

and Taste Adipose tissue in older individuals: a contributing factor to sarcopenia Asprosin regulates male