September 2022 "Systemic sclerosis (SSc) is a systemic autoimmune disease with the key features of inflammation, vasculopathy and fibrosis. This article focussed on emerging fields based on the authors’ current work and expertise. The authors provide a hierarchical structure into the studies of the pathogenesis of SSc starting with the contribution of environmental factors. Regulatory autoantibodies (abs) are discussed, which are parts of the human physiology and are specifically dysregulated in SSc. Abs against the angiotensin II receptor subtype 1 (AT1R) and the endothelin receptor type A (ETAR) are discussed in more detail. Extracellular vesicles are another novel player to possess disease processes. Fibroblasts are a key effector cell in SSc. Therefore, the current review will provide an overview about their plasticity in the phenotype and function. Promising nuclear receptors as key regulators of transcriptional programmes will be introduced as well as epigenetic modifications, which are pivotal to maintain the profibrotic fibroblast phenotype independent of external stimuli. Fibroblasts from SSc patients exhibit a specific signalling and reactivate developmental pathways and stem cell maintenance such as by employing hedgehog and WNT, which promote fibroblast-to-myofibroblast transition and extracellular matrix generation. Pharmacological interventions, although for other indications, are already in clinical use to address pathologic signalling." Read more at the source #DrGPCR #GPCR #IndustryNews

Grätz, Pawel Kozielewicz, et al. for their study on Frizzleds act as dynamic pharmacological entities Marina

Beth:  “We are looking for a thinker and problem solver who is able to learn.  So, if you are looking for an on-site opportunity in San Diego and Beth’s comments sound good to you,

Authors Mariana Bustamante Eduardo , Irene Keller , Nathalie Schuster , Stefan Aebi , Rolf Jaggi Tags

and records non-personal information on our server logs from your browser, including your IP address, cookie allows third-party companies presenting advertisements on some of our web pages to set and access their cookies Again, these cookies are not connected to any personal information. Ecosystem.DrGPCR.com and third-party vendors, including but not limited to Google, use first-party cookies (such as the Google Analytics cookie) and third-party cookies (such as the DoubleClick cookie) together

For the avoidance of doubt, this prohibition includes, but is not limited to, any use of pixels, cookies If you would like to use any of our brand features on your website, in an ad, in an article or book, This applies for print (book, magazine, journal, newspaper) or digital (webpage, DVD, CD, post) formats no superimposed graphics, photos, or ad copy on the screenshot and no changes to the way our product looks