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The lysine is so conserved that it is used to define a sequence as an opsin and thus phylogenetic opsin Thus, we call them gluopsins.

Thus, we need to know much more about the structures of receptor-ligand complexes at high resolution. Constituent structural motifs cooperatively transform ligand selectivity into specific functions, thus

Thus, we investigated the regulatory functions of its β-adrenergic-like octopamine receptor (PxOctβ3) This study demonstrated the pharmacological properties and functions of PxOctβ3 in P. xylostella, thus

protein has been recognized within myotubes and tissues of skeletal muscle from both murines and humans, thus Thus, the aim of the current research was to explore the influence of CB1 receptor stimulation and inhibition Thus, in skeletal muscle cells, a possible physiological expression of CB1 receptors was identified.

It plays a key role in the regulation of human calcium and thus mineral metabolism. Thus two WT VFT domains were required for normal Ca2+o potency and there was a pronounced gene-dosage

pivotal role in the regulation of the physiological balance between healthy and pathological conditions; thus associated with disease-associated changes in organismal tissue complexity and compartmentalization, thus

Thus, LYCHOS functions in a lysosomal pathway for cholesterol sensing and couples cholesterol concentrations

Thus, our data deepen the understanding of cholesterol modulation in GPCR (G protein-coupled receptor

concept for the modulation of isoform- and ligand specific aGPCR functions using unique tools, and thus

Thus, we identify astrocytes as active players in dopaminergic signaling in the PFC, contributing to

Thus, increased SHH activity due to ciliary dysfunction may be required for the development of pathoetiological

Thus, this review will cover specific roles of C3aR in driving cell type–specific and tissue specific

Thus, we systematically investigated the relationship between the concentration of two distinct pro-inflammatory

By means of these studies, we developed 14 as a fluorescent CCR2 ligand, enabling cell-free as well as Thus, our small-molecule-based fluorescent CCR2 ligand 14 represents a promising tool for future studies

remains poor, with an impacted quality of life during treatment coupled with brain tumour recurrence; thus

However, only a small fraction of these metabolites has been identified from the human microbiota thus

scaffolding of numerous cytoplasmic signaling complexes and assist in G-protein receptor signaling, thus

scaffolding of numerous cytoplasmic signaling complexes and assist in G-protein receptor signaling, thus

RNAi led to a low pupation rate (45.00%), body malformation, abnormal wing expansion, failed cuticle melanization

relationship that identifies small changes to the ligands that invert their pharmacological activity and thus

Thus, this study suggests that GPCR voltage dependency plays a role in many diverse neuronal functions

Thus, identifying novel molecular targets for developing HF therapeutics remains a key research focus

While no drugs targeting LPARs have been approved by the FDA thus far, at least three antagonists have

indicates that isozymes from both classes are involved, compensate for the absence of the other class, and thus

These results may supply new insights into GPER-mediated estrogen carcinogenesis in TNBC, thus providing

Thus, while farnesylated Gγ subunits are functionally active and largely interchangeable in supporting

Thus, the basolateral protein GPR125, an autocleavable adhesion GPCR, appears to play a crucial role

Thus, NF-α1/CPE uniquely interacts with serotonin receptor 5-HTR1E to activate the β-arrestin/ERK/CREB