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Authors Anna B Halpern , Eduardo Rodríguez-Arbolí , Megan Othus , Kelsey-Leigh A Garcia , Mary-Elizabeth

cancer invasion, highlighting its potential for therapeutic targeting. " Authors Elena Tomas Bort , Megan

that two well-known, approved drug classes - β-blockers and H1-antihistamines - may be beneficial and thus We thus believe that it is now time for a clinical trial involving these two agents in PDAC patients. inexpensive, largely safe drug classes, either alone or in combination, could prolong survival in PDAC and thus

Eddy began learning and investigating human GPCRs while training in the laboratories of Professors Raymond

She began her Ph.D. at Imperial College London with Prof Aylin Hanyaloglu, Prof Gary Frost, and Dr.

In 2014 David joined the University of Nottingham and began a part-time PhD in Molecular Pharmacology

He began his career in the late 1960s and has been an Investigator of the Howard Hughes Medical Institute

Most importantly, the GPCR Retreat dedicates time for two trainee symposia, an initiative that began

He primarily studies the chemokine receptor CXCR3 as it has three naturally occurring ligands and thus

These might serve as allosteric agonists of PAR1 on endothelial cells and platelets, and thus might contribute

Thus, we establish a critical role for efferocyte-derived vesicular mediators in increasing macrophage

A GPCR activation process based on the well-discerned conformational states is thus proposed, allosterically

Thus, the endogenous ligands and physiological functions of GPR87 are still required to be determined

Such a dual role of CCR7 as a GPCR that both senses and consumes its ligand can thus provide a novel

Thus, based on transcriptomic, proteomic, and phosphoproteomic differential expression data of GPR56

lithium) used for bipolar disorder therapy target signaling mechanisms regulated by dopamine receptors, thus

Thus, RGS proteins are essential in regulating GPCR signaling, and most members are implicated as critical

Thus, particle-delivered US28 fine-tunes Akt activity by limiting HCMV-induced EGFR activation during

I got my Bachelor's in Pharmacy from Minia University in 2011 and began my career as a teaching and research

These two mutations may disrupt the conserved ionic interaction between E6.30 and R3.50, and thus increase

demonstrated the strong binding affinity of gnetin A, gnetin C, (-)-viniferin, and resveratrol dimer, thus

Thus, OGR1 may be important to limit kidney crystal deposition, which might subsequently be relevant

lithium) used for bipolar disorder therapy target signaling mechanisms regulated by dopamine receptors, thus

Thus, our results identify LPAR-UCA1-let-7 axis as a novel avenue for targeted treatment strategies."

given that they are highly polymorphic proteins expressed as various alternatively spliced isoforms thus

Rouault "My contribution to science began during the equivalent of U.S. masters training at the Université

In 2013, Demet began her independent research career at the University of Chicago within the Department

GPRC5A) on lipopolysaccharide (LPS)-induced inflammatory response in human gingival fibroblasts (GFs), thus